Comparisons of the Therapeutic Effects of Dienogest and Danazol on Endometriosis

Objective: Women with adenomyosis or endometripsis are often suffered from dysmenorrhea or menorrhagia. Dienogest and danazol are frequently used for the treatment of endometriosis. However, there was no literature mentioned about which medication is better for the treatment of endometriosis. Thus, the aim of this study is to evaluate the efficacy between dienogest and danazol.

Methods: All consecutive women, who have endometriosis, will be randomized to receive dienogest or danazol treatment, and will assess symptoms severity, receive CA125 examination, sonographic examination at baseline, 4 weeks and 16 weeks after treatment.

• Dienogest (Drug): Dienogest 2 mg per day
• Danazol (Drug): Danzol 200MG per day

Primary outcomes

• The change of severity in dysmenorrhea [16 weeks]: Between-group difference in the score of global response assessment of dysmenorrhea

Secondary outcomes

• The change of severity in urinary symptoms [16 weeks]: Between-group difference in the score of UDI-6
• The change of severity in quality of life related to urinary symptoms [16 weeks]: Between-group difference in the score of IIQ-7
• The change of severity in menstrual amount [16 weeks]: Between-group difference in the score of global response assessment of menstrual amount

Sex: Female, ages: 20 Years to any

Inclusion Criteria:

* > 20 years old
* Have an endometriosis-related condition (including adenomyosis, adenomyoma, ovarian endometrioma, or pelvic endometriosis).

Exclusion Criteria:

* Minors.
* Have a history of breast cancer or other cancers.
* Patients with vascular obstruction such as stroke.