Study of Thyroid Status in Patients With IBD

NCT05542368 — Unknown, 90 participants, Assiut University

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Study of Thyroid State in Patients With Inflammatory Bowel Diseases

Registry	NCT05542368
Status	Unknown
Study type	Observational
Enrollment	90 (Estimated)
Sponsor	Assiut University (Other)
Conditions	Thyroid Disease, Irritable Bowel Disease
Interventions	Thyroid tests (Diagnostic test)
Dates	start 2022-12-01 (estimated), primary completion 2024-12-01 (estimated), completion 2024-12-01 (estimated), first posted 2022-09-15, last updated 2022-09-15
Locations	1 site in Egypt

-Summary

. The aim of the present study is to study thyroid state in patients with IBD

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+Detailed description

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction.

b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)

* ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin)

c)-Imaging:
* Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.

d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination

+Arms and interventions

Arm	Type	Interventions	Description
Patients with IBD		Diagnostic Test: Thyroid tests	All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) * ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: * Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity. d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination
Healty individuals as a control group		Diagnostic Test: Thyroid tests	All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction. b) Laboratory investigations: Thyroid function test (include T3-T4- TSH) * ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin) c)-Imaging: * Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.

Thyroid tests (Diagnostic test), also known as Thyroid function test and thyroid antibodies: Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin

+Outcome measures

Primary outcomes

Percentage of thyroid disorders in patients with IBD [1 year]: By use of Thyroid function test (include T3-T4- TSH), thyroid antibodies and thyroid sonography

+Eligibility

Sex: All, accepts healthy volunteers

Inclusion Criteria: All patients with IBD

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Exclusion Criteria:

* patients with
* Thyroid disease
* Acute or chronic kidney
* Acute or Chronic Liver Disease. Active Lupus -
* Malignancy
* patients taking medications that affect thyroid function as rifampin, amiodarone …..

+Locations (1)

Facility	City	Country	Status
Assiut University	Asyut	Egypt

+Investigators

Abo zaid Ali, assistant prof, Principal investigator, Assiut University