Prevalence of May-Thurner Syndrome in 1st-degree Relatives of Symptomatic Patients

May-Thurner syndrome (MTS) is a condition characterised by compression of the left common iliac vein by the right common iliac artery and the anterior spine of the 5th lumbar vertebrae. Previously thought to be a rare condition, the prevalence of MTS is thought to be underreported. MTS can lead to significant morbidity in the form of chronic venous insufficiency, venous ulceration, lower limb swelling, venous claudication, deep-vein thrombosis, varicose veins, pelvic congestion syndrome, chronic pelvic pain and chronic post-thrombotic syndrome. It is a known risk factor for development of venous incompetence and varicose veins in adolescents and young adults. Furthermore, it is known to be an a causative factor in the development of "unprovoked" DVT in younger patients, however data on the risk of development of DVT in MTS patients has to date, been unavailable.

The pathogenesis of MTS is largely unknown and whilst the condition is known to be more prevalent in females, familial risk factors are largely unknown. To date, no studies have previously assessed the prevalence of MTS in relatives of those with the condition.

• No Intervention (Other): No Intervention

Primary outcomes

• Prevalence Assessment [1 year]: To assess the prevalence of May-Thurner syndrome amongst 1st-degree relatives of symptomatic individuals referred to the Vascular Department, University Hospital Limerick using duplex ultrasound imaging

Secondary outcomes

• Venous Competence Assessment [1 year]: To assess concomitant venous incompetence of the lower limb

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Informed consent, first degree relative with symptomatic May-Thurner syndrome

Exclusion Criteria:

* Those who not give informed consent to be contacted or to be scanned.