Evaluation of Non-B Non-C Liver Cirrhosis in A EL-Rajhi Assuit University Hospital: A Retrospective-Prospective Study

NCT05314270 — Unknown, 100 participants, Assiut University

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Registry	NCT05314270
Status	Unknown
Study type	Observational
Enrollment	100 (Estimated)
Sponsor	Assiut University (Other)
Conditions	Non-B Non-C Liver Cirrhosis
Interventions	Diagnostic tests (Diagnostic test)
Dates	start 2022-10-01 (estimated), primary completion 2023-10-01 (estimated), completion 2023-11-01 (estimated), first posted 2022-04-06, last updated 2022-04-06

-Summary

To study the etiologies of patients diagnosed as non-B, non-C liver cirrhosis (NBNC-LC).

To describe the different patient's outcomes.

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+Detailed description

Liver cirrhosis is the ultimate fate of many hepatic insults that may be viral, immunologic, and metabolic or even cryptogenic. (Tsochatzis EA et al., 2014)

Recently, Non-Alcoholic Fatty Liver Disease (NAFLD) present a serious health burden worldwide that affects around 25% of the global adult population with a prevalence of around 31.8% in the Middle East. (Younossi ZM, et al., 2019)

Most of Egyptian patients presented with end-stage liver disease are secondary to post-hepatitic cirrhosis is estimated to be more than 80% of cases. (Guerra J et al., 2012)

The real profile of non-B, non-C etiologies of liver cirrhosis, in Egyptian patients, is still not fully evaluated.

+Arms and interventions

Diagnostic tests (Diagnostic test), also known as 24h copper in urine.. Iron profile.. Liver biopsy: Diaagnostic tests for all pt diagnosed as Non-B Non-C Liver Cirrhosis

+Outcome measures

Primary outcomes

Detection of different etiologies of liver cirrhosis that not related to HBV or HCV in our community [Base line]

Secondary outcomes

Detection of the most common etiologies of Non B Non C liver cirrhosis in our community [Baseline]

+Eligibility

Sex: All

Inclusion Criteria:

* All pateints diagnosed as Non-B Non-C Liver Cirrhosis in the period from 2017_2023

Exclusion Criteria:

* We will exclude the pateints that will be diagnosed as HBV-HCV induced Liver Cirrosis