German Cardiac Arrest Registry

NCT05142124 — Recruiting, 400 participants, Leipzig Heart Science gGmbH
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RegistryNCT05142124, acronym G-CAR
StatusRecruiting
Study typeObservational
Enrollment400 (Estimated)
SponsorLeipzig Heart Science gGmbH (Other); collaborators: Helios Health Institute GmbH, Heart Center Leipzig - University Hospital, IHF GmbH - Institut für Herzinfarktforschung, Universitätsklinikum Hamburg-Eppendorf, St. Antonius Hospital, Klinikum Ludwigshafen, University of Magdeburg, Charite University, Berlin, Germany, University Hospital of Cologne
ConditionsOut-of-hospital Cardiac Arrest
Datesstart 2021-07-21, primary completion 2026-12-31 (estimated), completion 2027-06-30 (estimated), first posted 2021-12-02, last updated 2026-02-12
Locations25 sites in Germany

Related Papers Related Patents Related Grants Related Experts
All trials for Out-of-hospital Cardiac Arrest

-Summary

In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

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+Outcome measures

Primary outcomes

  • In hospital mortality [until discharge, an average of 2 weeks]

Secondary outcomes

  • Length of ICU stay [until discharge, an average of 2 weeks]
  • Length of hospital stay [until discharge, an average of 2 weeks]
  • Mortality [Day 30]
  • Mortality [Month 6]
  • European Quality of Life 5 Dimensions 5 Level Version (EQ-5D) [Month 6]: five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'
  • Post Traumatic Stress Syndrome [Month 6]: PTSS-14
  • Reintegration [Month 6]: Reintegration to Normal Living Index
  • Hospital Anxiety and Depression Scale (HADS) [Month 6]: score 0-21; higher value show more severe depression
  • Mini Montreal Cognitive Assessment (MoCA) [Month 6]: score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction
  • Mini Montreal Cognitive Assessment (MoCA) [Month 12]: score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction
  • Mortality [Month 12]
  • European Quality of Life 5 Dimensions 5 Level Version (EQ-5D) [Month 12]: five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'
  • Post Traumatic Stress Syndrome (PTSS-14) [Month 12]: scor 14-98; higher value indicate more post traumatic stress
  • Reintegration [Month 12]: Reintegration to Normal Living Index
  • Hospital Anxiety and Depression Scale (HADS) [Month 12]: score 0-21; higher value indicate more severe depression

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

Exclusion Criteria:

* rejection of register participation by patient or legal representative

+Locations (25)

FacilityCityCountryStatus
CHARITE - Universitätsmedizin Berlin - Campus Virchow KlinikumBerlin, State of BerlinGermanyActive not recruiting
SLK-Kliniken Heilbronn - Klinikum am PlattenwaldBad FriedrichshallGermanyRecruiting
Charité Universitätsmedizin Berlin - Deutsches Herzzentrum BerlinBerlinGermanyRecruiting
Universitätsklinikum BonnBonnGermanyRecruiting
Bremer Institut für Herz- und Kreislaufforschung am Klinikum Links der WeserBremenGermanyRecruiting
Herzzentrum der Universität zu KölnCologneGermanyRecruiting
Herzzentrum Dresden GmbHDresdenGermanyActive not recruiting
Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und AngiologieDüsseldorfGermanyRecruiting
Elisabeth Krankenhaus Essen - Klinik für Akut- und NotfallmedizinEssenGermanyRecruiting
Klinikum Frankfurt HöchstFrankfurtGermanyRecruiting
Universitätsklinikum Halle (Saale)HalleGermanyRecruiting
Universitäres Herz- und Gefäßzentrum HamburgHamburgGermanyRecruiting
Asklepios Klinik St- Georg HamburgHamburgGermanyRecruiting
SLK-Kliniken Heilbronn - Klinikum am GesundbrunnenHeilbronnGermanyRecruiting
Universitätsklinikum des SaarlandesHomburgGermanyRecruiting
Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/CardiologyLeipzigGermanyRecruiting
Klinikum der Stadt Ludwigshafen gGmbHLudwigshafenGermanyRecruiting
Herzzentrum LübeckLübeckGermanyRecruiting
Universitätsklinikum MannheimMannheimGermanyRecruiting
Klinikum der Universität MünchenMünchenGermanyRecruiting
Marienhaus Klinikum HetzelstiftNeustadtGermanyRecruiting
Hegau-Bodensee KlinikumSingenGermanyRecruiting
Hegau-Bodensee-Klinikum SingenSingenGermanyNot yet recruiting
Schwarzwald-Baar Klinikum VSVillingen-SchwenningenGermanyRecruiting
Dr. Horst Schmidt KlinikenWiesbadenGermanyActive not recruiting

+Publications

  • Results publication: Rossberg M, Heerklotz H, Hosler N, Ouarrak T, Desch S, Thiele H, Zeymer U, Tigges E, Voigt I, Michels G, Voss F, Apfelbacher C, Freund A, Ewen S, Fleischmann-Struzek C, Sinning C, Poss J; G-CAR Investigators. Cognition, Quality of Life, and Psychological Outcomes in Out-of-Hospital Cardiac Arrest Survivors - Results from the German Cardiac Arrest Registry (G-CAR). Resuscitation. 2026 Aug 24:111277. doi: 10.1016/j.resuscitation.2026.111277. Online ahead of print. PMID 42637214
  • Results publication: Poss J, Sinning C, Rossberg M, Hosler N, Ouarrak T, Bottiger BW, Ewen S, Wienbergen H, Voss F, Dutzmann J, Tigges E, Voigt I, Freund A, Desch S, Michels G, Thiele H, Zeymer U; G-CAR Investigators. German Cardiac Arrest Registry (G-CAR)-results of the pilot phase. Clin Res Cardiol. 2025 Oct;114(10):1270-1279. doi: 10.1007/s00392-024-02468-5. Epub 2024 Jun 13. PMID 38869632
  • Results publication: Poss J, Sinning C, Schreiner I, Apfelbacher C, Drewitz KP, Hosler N, Schneider S, Pieske B, Bottiger BW, Ewen S, Wienbergen H, Kelm M, Bock D, Graf T, Adler C, Dutzmann J, Knie W, Orban M, Zeymer U, Michels G, Thiele H; G-CAR Investigators. German Cardiac Arrest Registry: rationale and design of G-CAR. Clin Res Cardiol. 2023 Apr;112(4):455-463. doi: 10.1007/s00392-022-02044-9. Epub 2022 Jun 21. PMID 35729429

+Investigators

  • Janine Pöss, Dr., Study chair, Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology