Evaluating the Response of the Immune System of People With Long COVID (Post SARS-CoV-2)

Patients who attend the Long Covid Recovery Clinic at Huntington Hospital will be offered participation in the study. After giving written informed consent, their medical history along with a description of clinical symptoms given through an extensive questionnaire will be accessed. Venous blood will be collected as a baseline and then at follow up visits (as dictated by changes in clinical symptomatology) for evaluation of corollary immune parameters. Patients will be followed at a minimum of every 2 months for 2 years.

Primary outcomes

• Correlation of symptomatology with inflammatory profiles in patients with Post-Acute Sequelae of SARS-CoV2 (PASC) [From onset of infection to 24 months]: Do patient symptoms correlate with abnormalities in inflammatory profiles?
• Identification of immunologic and inflammatory features of PASC based on results of immunologic and inflammatory assays [From onset of infection to 24 months]: Are there abnormalities in immunologic and inflammatory assays unique to PASC?
• Evaluation and delineation of the pathologic pathways and long-term effects of SARS-CoV2 infection [From onset of infection to 60 months]: What are the pathological pathways and long-term effects of SARS-CoV2?
• Identification of risks factor for PASC [From onset of infection to 24 months]: What are the risk factors for PASC?
• Identification of potential sites of therapeutic intervention to ameliorate symptomatology of PASC [From onset of infection to 60 months]: Are there potential sites of therapeutic intervention to relieve the symptoms of PASC?

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Enrolled in Huntington Hospital\'s Long Covid Recovery Clinic
* Documented previous infection with SARS-CoV2
* Symptoms suggestive of post-acute sequelae of SARS-CoV2 (including but not limited to chronic fatigue, brain fog, muscle and joint pain, cardiac and pulmonary issues, or other factors related to their acute COVID-19 event)
* Signed Informed Consent Form

Exclusion Criteria:

* No documented positive SARS-CoV2 serologies
* No post-acute sequelae of SARS-CoV2 symptomatology
* Incarcerated

• Kimberly Shriner, MD, Principal investigator, Huntington Hospital