Assessment of the Effect of Restriction on Alimentary AGE in Progression of Chronic Kidney Disease

NCT04827290 — Not applicable, Unknown, 66 participants, Centre Hospitalier Saint Joseph Saint Luc de Lyon

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Assessment of the Effect of Restriction on Alimentary AGE (Advanced Glycation Products) in Progression of Chronic Kidney Disease (CKD)

Registry	NCT04827290, acronym CKD AGE
Status	Unknown
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, prevention
Enrollment	66 (Estimated)
Sponsor	Centre Hospitalier Saint Joseph Saint Luc de Lyon (Other)
Conditions	Kidney Failure, Chronic, Chronic Kidney Disease stage3, Chronic Kidney Disease Stage 3B, Chronic Kidney Disease Stage 3A (Disorder), Chronic Kidney Disease, Stage 3 (Moderate), Diet Habit
Interventions	Low-AGE diet, High-AGE diet (Behavioral)
Dates	start 2024-08-01 (estimated), primary completion 2025-08-01 (estimated), completion 2025-09-01 (estimated), first posted 2021-04-01, last updated 2024-04-04
Locations	1 site in France

-Summary

Normal-protein and low-AGE through raw or rare proteins diet versus normal-protein and high-AGE diet in stage IIIa-b renal failure patients

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
Normal-protein and low-AGE through raw or rare proteins diet	Experimental	Behavioral: Low-AGE diet	Normal-protein (0,8g/kg/day) and low-AGE through raw or rare proteins diet during 24 months
Normal-protein and AGE-rich diet	Active comparator	Behavioral: High-AGE diet	Normal-protein (0,8g/kg/day) and high-AGE through overcooked proteins diet during 24 months

Low-AGE diet (Behavioral): Low-AGE diet during 24 months
High-AGE diet (Behavioral): High-AGE diet during 24 months

+Outcome measures

Primary outcomes

Glomerular Filtration Rate [At 24 months]: Glomerular Filtration Rate estimated by the CKD-EPI formula with a blood sample

Secondary outcomes

Proteinuria [At 24 months]: Proteinuria (g/24h) found in the 24-hour urine

+Eligibility

Sex: All, ages: 18 Years to 89 Years

Inclusion Criteria:

* Patients with a grade IIIA-B CKD (GFR with CKD-EPI ≥ 30 mL/min and < 60mL/min)
* Informed consent signed
* Aged 18 to 89 years

Exclusion Criteria:

* Protected adult
* Acute renal failure
* Patient already on a low-AGE diet (< 1kU AGE/day) following a dietetic consultation
* Current participation in another interventional research

+Locations (1)

Facility	City	Country	Status
Centre Hospitalier Saint Joseph Saint Luc	Lyon	France