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The Effect of the Severity of COVID-19 Disease on the Incidence of Acute Renal Failure in ICU

NCT04799600 — Completed, 158 participants, Ankara City Hospital Bilkent

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RegistryNCT04799600
StatusCompleted
Study typeObservational
Enrollment158 (Actual)
SponsorAnkara City Hospital Bilkent (Other)
ConditionsCOVID19, Acute Renal Failure
InterventionsBRESCİA-COVİD Respiratory Severity Scale (Other)
Datesstart 2020-09-01, primary completion 2021-06-15, completion 2021-07-01, first posted 2021-03-16, last updated 2021-07-27
Locations1 site in Turkey (Türkiye)

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-Summary

Aim of the study is to determinate the frequency of acute renal failure in COVID-19 patients, its relationship with the severity of COVID-19 disease in ICU, and the ability to take precautions against these factors.

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+Arms and interventions

ArmTypeInterventionsDescription
Acute Renal Failure in ICUOther: BRESCİA-COVİD Respiratory Severity ScaleCOVID-19 Patients with Acute Renal Failure in ICU
  • BRESCİA-COVİD Respiratory Severity Scale (Other): KDIGO acute renal failure score BRESCİA-COVID Respiratory Severity Score

+Outcome measures

Primary outcomes

  • KDIGO criteria [6 months]: KDIGO Criteria stage 1: Increase in SCr by ≥ 0.3 mg/dL within 48 hours or increase in SCr 1.5 to 1.9 times baseline which is known or presumed to have occurred within the prior 7 days Stage 2: 2.0 to 2.9 multiplied by baseline SCr; Stage 3: 3.0 or more multiplied by baseline; increase in SCr ≥ 4.0 mg/dL; or beginning of renal replacement therapy regardless of a previous KDIGO stage.
  • BRESCIA-COVID RESPIRATORY SEVERITY SCALE (BCRSS) scores [6 months]: The BCRSS score (between level 0-8) is calculated from "www.mdcalc.com/brescia-covid-respiratory-severity-scale-bcrss-algorithm" according to the severity of COVID disease , respiratory rate, PaO2 level, chest x-ray, and clinical status.

+Eligibility

Sex: All, accepts healthy volunteers

Inclusion Criteria:

Patients hospitalized in the intensive care unit diagnosed with COVID-19 will include in the study.

Exclusion Criteria:

there is no exclusion criteria

+Locations (1)

FacilityCityCountryStatus
Ankara City HospitalAnkaraTurkey (Türkiye)

+Publications

  • Results publication: Kellum JA, Lameire N; KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care. 2013 Feb 4;17(1):204. doi: 10.1186/cc11454. PMID 23394211
  • Results publication: Wang L, Li X, Chen H, Yan S, Li D, Li Y, Gong Z. Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. Am J Nephrol. 2020;51(5):343-348. doi: 10.1159/000507471. Epub 2020 Mar 31. PMID 32229732
  • Results publication: Rodriguez-Nava G, Yanez-Bello MA, Trelles-Garcia DP, Chung CW, Friedman HJ, Hines DW. Performance of the quick COVID-19 severity index and the Brescia-COVID respiratory severity scale in hospitalized patients with COVID-19 in a community hospital setting. Int J Infect Dis. 2021 Jan;102:571-576. doi: 10.1016/j.ijid.2020.11.003. Epub 2020 Nov 9. PMID 33181332

+Investigators

  • betül aytaç, MD, Principal investigator, ankara ch bilkent

My Notes