Oxidative Stress Markers in COPD

NCT04748887 — Completed, 70 participants, Minia University

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Chronic Obstructive Pulmonary Disease in Non Smokers:Role of Oxidative Stress

Registry	NCT04748887
Status	Completed
Study type	Observational
Enrollment	70 (Actual)
Sponsor	Minia University (Other)
Conditions	Role of Oxidative Stress in COPD
Interventions	oxidative stess markers (Other)
Dates	start 2018-09-01, primary completion 2019-04-01, completion 2019-09-01, first posted 2021-02-10, last updated 2021-02-10
Locations	1 site in Egypt

-Summary

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
nonsmokers copd cases ,		Other: oxidative stess markers	Fourty subjects of COPD who are non-smokers or stopped smoking for more than 6 months
non smokers healthy control		Other: oxidative stess markers	Thirty subjects of non smokers healthy control

oxidative stess markers (Other), also known as Superoxide Dismutase (SOD) and Malondialdehyde (MDA): markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

+Outcome measures

Primary outcomes

oxidative stress markers in non smokers COPD compared to healthy control [1month]: markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

+Eligibility

Sex: All

Inclusion Criteria:

* 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control

Exclusion Criteria:

* Patients of:

  1. Acute exacerbation, at the time of the study, of COPD.
  2. Any obvious abnormal lung parenchymal lesions.
  3. Lung cancer.
  4. Congestive heart failure.
  5. current smokers
  6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

+Locations (1)

Facility	City	Country	Status
Minia University Hospital	Multiple Locations, Minya Governorate	Egypt

+Investigators

zainab H Saeed, MD, Principal investigator, MD chest diseases