Clinical Evaluation of a Multipurpose CZT Camera in Gated Tomographic Radionuclide Angiography: a Head to Head Comparison With a Cardiac Dedicated CZT Device
| Registry | NCT04629937, acronym STARGAC |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; na, single group, masking: none, other |
| Enrollment | 73 (Actual) |
| Sponsor | Centre Hospitalier Régional d'Orléans (Other) |
| Conditions | Cardiac Function |
| Interventions | SPECT acquisitions (Other) |
| Dates | start 2020-12-30, primary completion 2021-08-06, completion 2021-08-06, first posted 2020-11-16, last updated 2022-07-18 |
| Locations | 1 site in France |
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All trials for Cardiac Function All trials of SPECT acquisitions
Tomographic radionuclide angiography (or blood pool) is a reproducible method to evaluate left ventricular ejection fraction that is needed during oncological treatments or to evaluate cardiopathies.
Cardiac-dedicated CZT systems allowed dose or time reduction. Multipurpose CZT cameras have not yet been evaluated in this indication. Moreover, the impact of attenuation correction is not known.
Tomographic radionuclide angiography is a simple, rapid and reproducible method of cardiac function measurement, including left (LVEF) and right (RVEF) ventricular ejection fractions.
In addition to cardiological indications, this examination is often performed as part of cardiac toxicity screening during the various oncological treatments. This indication is all the more true since the arrival of CZT gamma cameras dedicated to cardiological studies has made it possible to reduce injected activities, as well as examination times.
The multipurpose CZT camera allows tomoscintigraphic acquisitions to be carried out using CZT technology as well. Unlike the CZT gamma cameras dedicated to cardiological studies, this system can be used for the exploration of different organs, and also allows the realization of CT slices for attenuation correction.
Patients included in this study will be double scanned both on a dedicated cardiac CZT camera and on multipurpose CZT camera, with CT. LVEF and RVEF will be then compared.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| SPECT acquisitions | Experimental | Other: SPECT acquisitions | All patients will undergo SPECT acquisitions with both multipurpose CZT camera and cardiac dedicated CZT camera. |
Sex: All, ages: 18 Years to any
Inclusion Criteria: * Patients referred to our Nuclear Medicine department for evaluation of cardiac function. Exclusion Criteria: * Patients treated with chemotherapy within 12 days. * Under 18 years old patients. * Pregnant women or at risk of pregnancy. * Breast feeding. * Painful patients. * Patients under guardianship. * Patients in whom a standard examination is not feasible (agitation). * Patients who do not benefit from a social security system
| Facility | City | Country | Status |
|---|---|---|---|
| CHR d'Orleans | Orléans | France |