Case Fatalities in Hospitalised COVID-19 Patients in the UK

NCT04527458 — Completed, 70000 participants, University of Edinburgh

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Case Fatalities in Hospitalised COVID-19 Patients in the UK: An ISARIC Study

Registry	NCT04527458
Status	Completed
Study type	Observational
Enrollment	70000 (Actual)
Sponsor	University of Edinburgh (Other); collaborators: International Severe Acute Respiratory and Emerging Infection Consortium, BREATHE Health Data Research Hub
Conditions	Covid19
Interventions	Patient Characteristics, COVID-19 treatments, Differences in triage, Surge capacity (Other)
Dates	start 2020-02-24, primary completion 2020-08-02, completion 2020-08-02, first posted 2020-08-26, last updated 2020-08-26
Locations	1 site in United Kingdom

-Summary

This study will investigate how the case fatality in hospitalised patients with COVID-19 has changed throughout the pandemic. It will also explore possible mechanisms that could be driving these changes. This analysis will enhance our understanding of the virus, which will be important for researchers and clinicians to respond appropriately.

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+Arms and interventions

Arm	Type	Interventions	Description
Hospitalisations		Other: Patient Characteristics; Other: COVID-19 treatments; Other: Differences in triage; Other: Surge capacity	All hospitalised COVID patients
Critical care		Other: Patient Characteristics; Other: COVID-19 treatments; Other: Differences in triage; Other: Surge capacity	All hospitalised COVID patients in critical care

Patient Characteristics (Other): Characteristics of the patients
COVID-19 treatments (Other): Specific treatments used on COVID-19 patients
Differences in triage (Other): Triage criteria for treating COVID-19 patients
Surge capacity (Other): Capacity of hospitals

+Outcome measures

Primary outcomes

Case fatality [23 weeks]: The proportion of new admissions with COVID-19 who died over time

+Eligibility

Sex: All

Inclusion Criteria:

* All patients admitted with a proven or high likelihood of COVID-19

+Locations (1)

Facility	City	Country	Status
University of Edinburgh	Edinburgh	United Kingdom

+Publications

Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJ, Baillie JK, Semple MG; ISARIC4C investigators. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020 May 22;369:m1985. doi: 10.1136/bmj.m1985. PMID 32444460

+Investigators

Annemarie B Docherty, Principal investigator, Usher Institute, University of Edinburgh
Ewen M Harrison, Principal investigator, Usher Institute, University of Edinburgh
Rachel H Mulholland, Principal investigator, Usher Institute, University of Edinburgh