| Registry | NCT04522947 |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; na, single group, masking: none, other |
| Enrollment | 187 (Actual) |
| Sponsor | University of Nebraska Lincoln (Other); collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Stanford University, University of Utah, Gretchen Swanson Center for Nutrition, Wayne State University |
| Conditions | Obesity |
| Interventions | Milkshake fMRI (Other) |
| Dates | start 2020-10-30, primary completion 2025-04-24, completion 2025-04-24, first posted 2020-08-21, last updated 2026-01-12 |
| Locations | 1 site in United States |
Related Papers Related Patents Related Grants Related Experts
All trials for Obesity All trials of Milkshake fMRI
The purpose of this study is to examine patterns of neural activation in a priori selected brain regions associated with reward process during anticipation and delivery of appetizing food stimuli (milkshake sips) among young adults.
This observational trial seeks to examine neural activation patterns in a food reward sensitivity task. The study uses the "milkshake" MRI task to assess individual food reward sensitivity in a sample of young adult participants. Participants are presented with a series of trials in which a visual cue is provided (either a glass of milkshake or water), followed by delivery of a sip of the corresponding liquid. Activation in a priori regions associated with reward processing is measured via blood oxygen level-dependent (BOLD) signal, both in response to the cue and actual delivery of the sip. Explicating patterns of reward processing for appetizing food stimuli holds potential to inform understanding of the neural underpinnings of obesity risk.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| fMRI | Experimental | Other: Milkshake fMRI | Participants are delivered sips of appetizing tastes (milkshake) and tasteless solution throughout the task while in the MRI scanner. |
Sex: All, ages: 19 Years to any, accepts healthy volunteers
Inclusion Criteria: * Age 19 years or older * Previous participation in the Preschool Problem Solving Study OR lived in Lancaster County, NE for at least part of high school Exclusion Criteria: * Contraindications for functional magnetic resonance imaging (fMRI): * metal in body * pregnancy * braces * non-removal piercings * hair extensions * As of 8/13/21, for individuals who were not in the Preschool Problem Solving Study but are invited to participate in the current study because they lived in Lancaster County for at least part of high school, the maximum age for eligibility is 20 years of age.
| Milestone | fMRI Milkshake Task |
|---|---|
| Started | 187 |
| Completed | 187 |
| Not completed | 0 |
Time frame: During the session in which the milkshake task trial was conducted
| Arm | Deaths | Serious adverse events | Other adverse events |
|---|---|---|---|
| fMRI Milkshake Task | 0/187 (0.0%) | 0/187 (0.0%) | 0/187 (0.0%) |
| Facility | City | Country | Status |
|---|---|---|---|
| University of Nebraska-Lincoln | Lincoln, Nebraska | United States |
NIH grants: R01DK125651