Comparison of Magnetic Resonance Techniques for the Measurement of Cerebral Blood Perfusion

NCT04486248 — Completed, 30 participants, Barcelonabeta Brain Research Center, Pasqual Maragall Foundation

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Registry	NCT04486248
Status	Completed
Study type	Observational
Enrollment	30 (Actual)
Sponsor	Barcelonabeta Brain Research Center, Pasqual Maragall Foundation (Other)
Conditions	Healthy
Dates	start 2019-10-09, primary completion 2020-02-24, completion 2022-12-31, first posted 2020-07-24, last updated 2023-03-31
Locations	1 site in Spain

-Summary

In this project, we aim at implementing a te-ASL sequence and to compare it to two reference ASL sequences with a fixed PLD on healthy individuals. On the one hand, the te-ASL sequence will be compared against a 3D pCASL with a PLD of 1800 ms, as the current reference according the Consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. On the other, as the implemented te-ASL sequence will have a 2D readout, it will also be compared to a 2D pCASL ASL sequence with the same PLD, in order to be able to disentangle differences due to the dynamic PLD scheme from those arising from the different read-out schemes.

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+Outcome measures

Primary outcomes

ASL perfusion MRI data [Through study completion, an average of 1 year]: Quantification of cerebral blood flow

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* To sign the study informed consent form approved by the corresponding authorities.
* Healthy men and women (older than 18 years old).

Exclusion Criteria:

* Inability or unwillingness to give written informed consent or communicate with the study staff or illiteracy.
* Any contraindication to perform brain MRI procedure (e.g. pacemaker, MRI-incompatible aneurysm clips).

+Locations (1)

Facility	City	Country	Status
BarcelonaBeta Brain Research Center	Barcelona	Spain