Immune Homeostasis in Patients With Sepsis and Septic Shock: a Single Center Observational Study
| Registry | NCT04448951, acronym IMHOTEP |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Enrollment | 200 (Estimated) |
| Sponsor | Charles University, Czech Republic (Other) |
| Conditions | Sepsis, Immunologic Paralysis, Immunologic Suppression, Immune Deficiency |
| Interventions | transcriptomics, flow-cytometry, cytokines (Other) |
| Dates | start 2020-09-01, primary completion 2025-08-31 (estimated), completion 2027-12-31 (estimated), first posted 2020-06-26, last updated 2024-08-21 |
| Locations | 1 site in Czechia |
Related Papers Related Patents Related Grants Related Experts
All trials for Sepsis All trials for Immunologic Paralysis All trials of transcriptomics All trials of flow-cytometry
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| sepsis/septic shock | Other: transcriptomics; Other: flow-cytometry; Other: cytokines | target population | |
| non-septic critically ill | Other: transcriptomics; Other: flow-cytometry; Other: cytokines | demographically-matched control group | |
| healthy control | Other: transcriptomics; Other: flow-cytometry; Other: cytokines | control group |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: * sepsis/septic shock (SEPSIS-3) * age ≥18 * informed consent * inclusion within first 24hrs after development/diagnosis of septic shock Exclusion Criteria: * disagreement of the patient or legal representative with the entry into the study * patients with primary or secondary immunodeficiency * presence of active haematological malignancy or an active non-haematological malignancy
| Facility | City | Country | Status |
|---|---|---|---|
| Medical ICU, 1st Dept. of Internal Medicine, Teaching Hospital in Pilsen | Pilsen, Česká Republika | Czechia | Recruiting |