Identifying Leucocyte and Urine Biomarkers in Parkinson's Patients With LRRK2 G2385R Gene Variant
| Registry | NCT04436848, acronym LRRK2 G2385R |
|---|---|
| Status | Unknown |
| Study type | Observational |
| Enrollment | 150 (Estimated) |
| Sponsor | University of Malaya (Other); collaborators: Michael J. Fox Foundation for Parkinson's Research, University of Dundee, Nextcea, Inc, Max Planck Institute of Biochemistry |
| Conditions | Parkinson Disease |
| Interventions | This is a non-interventional study (Other) |
| Dates | start 2020-06-01, primary completion 2021-12-31 (estimated), completion 2022-06-30 (estimated), first posted 2020-06-18, last updated 2020-06-18 |
| Locations | 1 site in Malaysia |
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Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor (MLi-2) on these biomarkers, using immunoblotting and mass spectrometry.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| PD patients positive for LRRK2 G2385R | Other: This is a non-interventional study | ||
| PD patients negative for LRRK2 G2385R | Other: This is a non-interventional study | ||
| Non-PD controls negative for LRRK2 G2385R | Other: This is a non-interventional study |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: * Diagnosis of Parkinson's disease assigned by a movement disorder specialist according to clinical diagnostic criteria * Age above 18 year-old * Provision of a written informed consent Exclusion Criteria: \- Physical or mental incapacity to complete study protocol
| Facility | City | Country | Status |
|---|---|---|---|
| University of Malaya Medical Centre | Kuala Lumpur | Malaysia | Recruiting |