Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen

NCT04435223 — Completed, 62 participants, Centre Hospitalier Universitaire Dijon

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Registry	NCT04435223, acronym COVIDOLIP
Status	Completed
Study type	Observational
Enrollment	62 (Actual)
Sponsor	Centre Hospitalier Universitaire Dijon (Other)
Conditions	COVID-19 Severe Pneumonia, Severe Pneumonia Due to Other Pathogene
Interventions	biological assays in particular on the lipid metabolism (Biological)
Dates	start 2020-04-07, primary completion 2020-05-07, completion 2020-05-07, first posted 2020-06-17, last updated 2026-02-02
Locations	1 site in France

-Summary

SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.

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+Arms and interventions

Arm	Type	Interventions	Description
COVID-19 severe pneumonia		Biological: biological assays in particular on the lipid metabolism
Severe pneumonia due to other pathogene		Biological: biological assays in particular on the lipid metabolism

biological assays in particular on the lipid metabolism (Biological): bioassays carried out on samples already collected and conserved

+Outcome measures

Primary outcomes

Cholesterol concentration [Within 48 hours following hospital admission]

Secondary outcomes

LDL cholesterol / HDL cholesterol/ Lipoprotein size and composition/ Non esterified Fatty acid/ Triglyceridemia/ CETP and PLTP activity/ apolipoprotein canceration/ lipid peroxidation/ Pro and anti inflammatory profile. [Within 48 hours following hospital admission]: Ventilator free days (28 days)

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* 2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (>=38 °C) Hypothermia (< 35°C) AND new radiologic pulmonary infiltrate
* At admission or within 48 hours following hospital admission
* With 2 qSOFA criteria: MAP =< 100 mmHg, Respiratory Rate >= 22, Glasgow score < 15 OR on mechanical ventilation OR under vasopressor
* Age > 18
* affiliated to social security

Exclusion Criteria:

* Pregnancy
* immunodepression
* Pathology known to cause severe lymphopenia
* hospitalisation within 3 month before inclusion AND sepsis

+Locations (1)

Facility	City	Country	Status
Chu Dijon Bourgogne	Dijon	France

+Publications

Results publication: Nguyen M, Bourredjem A, Piroth L, Bouhemad B, Jalil A, Pallot G, Le Guern N, Thomas C, Pilot T, Bergas V, Choubley H, Quenot JP, Charles PE, Lagrost L, Deckert V, de Barros JP, Guinot PG, Masson D, Binquet C, Gautier T, Blot M; Lymphonie study group. High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia. Sci Rep. 2021 May 24;11(1):10824. doi: 10.1038/s41598-021-90362-9. PMID 34031519

My Notes

Public

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