| Registry | NCT04282525, acronym ECMOX1 |
|---|---|
| Status | Completed |
| Study type | Observational |
| Enrollment | 30 (Actual) |
| Sponsor | Nantes University Hospital (Other); collaborators: Istituto Giannina Gaslini, University of Cambridge |
| Conditions | Extracorporeal Membrane Oxygenation Complication |
| Interventions | ECMO for hemodynamic or respiratory indication (Other) |
| Dates | start 2018-06-01, primary completion 2019-06-01, completion 2019-06-01, first posted 2020-02-24, last updated 2020-02-24 |
| Locations | 1 site in France |
Related Papers Related Patents Related Grants Related Experts
All trials for Extracorporeal Membrane Oxygenation Complication All trials of ECMO for hemodynamic or respiratory indication
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor. Our first objective is to investigate the feasibility of CA continuous monitoring during ECMO treatment. The second objective is to analyze the relationship between CA impairment and neurological outcome.
Patients : All children treated by ECMO in the PICU of the Universitary hospital of Nantes, France and of IRCCS Giannina Gaslini Institute, Genoa, Italy
Measurements: A correlation coefficient between the variations of regional cerebral oxygen saturation (rScO2) as a surrogate of cerebral blood flow and the variations of arterial blood pressure (ABP) is calculated as an index of autoregulation (cerebral oxygenation index (COx), ICM+ software®). CA is monitored either on left (COxl) or both sides. A COx > 0.3 is considered as critical. Neurological outcome is assessed by the onset of an acute neurologic event (ANE) during the ECMO run.
Sex: All, ages: 1 Day to 18 Years
Inclusion Criteria: * Patients 18 years treated by ECMO Exclusion Criteria: * Lack of parental consent
| Facility | City | Country | Status |
|---|---|---|---|
| University Hospital | Nantes, Loire-Atlantique | France |