Exercise Intervention on Conflict Monitoring in Children With Attention-deficit Hyperactivity Disorder

NCT04112758 — Not applicable, Completed, 110 participants, National Taiwan Normal University

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The Effect of Long-term High-intensity Interval Training on Conflict Monitoring in Children With ADHD: an ERP and sLORETA Study

Registry	NCT04112758, acronym ADHD
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: none, other
Enrollment	110 (Actual)
Sponsor	National Taiwan Normal University (Other)
Conditions	Exercise Intervention
Interventions	High-intensity interval training (Other)
Dates	start 2020-06-01, primary completion 2021-04-30, completion 2022-01-23, first posted 2019-10-02, last updated 2023-01-18
Locations	1 site in Taiwan

-Summary

The study mainly investigates the effect of high-intensity interval training on conflict monitoring in children with ADHD by using event-related potential and sLORETA techniques.

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+Detailed description

The present study will have two experiments, one is a cross-section study and the other is intervention study.

As for cross-section study, typical developmental children and children with ADHD will perform the stroop task while recording their brain waves.

The intervention is twice a week for 5 weeks and before and after the intervention, children with ADHD will randomly assign to either an exercise group or control group. They will perform the stroop task while recording their brain waves.

+Arms and interventions

Arm	Type	Interventions	Description
Exercise group	Experimental	Other: High-intensity interval training	The group will receive twice a week for 5 week
Control group	No intervention		The group will be maintained their normal after school activities

High-intensity interval training (Other): 2 times weekly for 5 weeks Circuit training with 4 stations

+Outcome measures

Primary outcomes

Behavioral performance [Day 0 and post-intervention at Week 5]: reaction time (ms) is generated by computerized task deﬁned as correct responses within the range from 200-1500 ms
Behavioral performance [Day 0 and post-intervention at Week 5]: response accuracy (percentage) is generated by computerized task defined as percentage of trials that successfully responded to target stimulus

Secondary outcomes

N2 & P3 components [Day 0 and post-intervention at Week 5]: Electroencephalographic (EEG) activity will be measured at 64 sites. The amplitude of the N2 is deﬁned as the mean amplitude within a 50-ms interval surrounding the maximal negative peak within a 200- to 400-ms latency window. The amplitude of the P3 is deﬁned as the mean amplitude within a 50-ms interval surrounding the maximal positive peak within a 300- to 800-ms latency window.

Other outcomes

Brain activation [Day 0 and post-intervention at Week 5]: To examine sources relating to amplitude in ERPs, source localization will be conducted using standardized low resolution brain electromagnetic tomography (sLORETA) The sLORETA analysis with the ERP data will be selected by four 100 ms bins covering the period from 0 to 200 ms after stimulus-onset (0-50, 50-100, 100-150, and 150-200 ms).

+Eligibility

Sex: All, ages: 7 Years to 12 Years, accepts healthy volunteers

Inclusion Criteria:

1. age between 7 and 12 years
2. diagnosed with ADHD by a pediatric psychiatrist, which is not required for TD
3. no history of brain injury or neurological conditions, such as exhibited epileptic seizures, serious head injuries, and periods of unconsciousness.

Exclusion Criteria:

1. cannot follow the instruction
2. cannot complete all the procedure

+Locations (1)

Facility	City	Country	Status
National Taiwan Normal University	Taipei	Taiwan