Iron Absorption and Exercise

NCT04079322 — Not applicable, Completed, 31 participants, Florida State University

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Fractional Iron Absorption in Response to an Acute Bout of Exercise

Registry	NCT04079322
Status	Completed
Phase	Not applicable
Study type	Interventional; non randomized, crossover, masking: none, basic science
Enrollment	31 (Actual)
Sponsor	Florida State University (Other)
Conditions	Iron-deficiency, Iron Deficiency Anemia
Interventions	Meal (Other)
Dates	start 2019-08-22, primary completion 2019-12-04, completion 2019-12-04, first posted 2019-09-06, last updated 2020-02-27
Locations	1 site in United States

-Summary

Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.

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+Arms and interventions

Arm	Type	Interventions	Description
Exercise	Experimental	Other: Meal	During the exercise arm, volunteers will complete a planned workout, as prescribed by the coach. The workout will be designed to be strenuous and induce an inflammatory response.
Rest	Experimental	Other: Meal	The rest arm will be coordinated with a planned non-workout day, as prescribed by the coach, where volunteers are either scheduled to not run or go for an easy recovery run (<6 miles at a self-described "easy" pace) later in the afternoon.

Meal (Other): Participants will consume a meal containing a stable iron isotope following exercise or rest.

+Outcome measures

Primary outcomes

Change in fractional iron absorption [Red blood cells collected on day 0 and day 14]: Stable iron isotopes

Secondary outcomes

Change in concentration of ferritin in ng/mL [Day 0 and day 14]: Blood measure
Change in concentration of soluble transferrin receptor in nmol/L [Day 0 and day 14]: Blood measure
Change in concentration of hemoglobin in g/L [Day 0 and day 14]: Blood measure
Change in concentration of hematocrit as % [Day 0 and day 14]: Blood measure
Change in concentration of hepcidin in ng/mL [Day 0 and day 14]: Blood measure
Change in concentration of IL-6 in pg/mL [Day 0 and day 14]: Blood measure

+Eligibility

Sex: All, accepts healthy volunteers

Inclusion Criteria:

* Members of the Florida State University Cross Country team
* Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days
* Refrain from using vitamin or mineral supplements on the study days

Exclusion Criteria:

* Musculoskeletal injury that compromise the ability to exercise

+Locations (1)

Facility	City	Country	Status
Florida State University	Tallahassee, Florida	United States

+Publications

Results publication: Barney DE Jr, Cheung SN, Harris AR, Berryman CE, Hennigar SR. Dietary Intake and Diet Quality of Female and Male NCAA Division I Cross Country Runners from a Single University. Curr Dev Nutr. 2024 Oct 15;8(11):104475. doi: 10.1016/j.cdnut.2024.104475. eCollection 2024 Nov. PMID 39610765
Results publication: Barney DE, Ippolito JR, Berryman CE, Hennigar SR. A Prolonged Bout of Running Increases Hepcidin and Decreases Dietary Iron Absorption in Trained Female and Male Runners. J Nutr. 2022 Sep 6;152(9):2039-2047. doi: 10.1093/jn/nxac129. PMID 35661896

+Funding

NIH grants: 2019

My Notes

Public

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