Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

NCT04006483 — Completed, 2359 participants, Procter and Gamble

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A Review of Meta-Analyses on Bioavailable Stannous Fluoride Dentifrices: Effects on Dental Plaque

Registry	NCT04006483
Status	Completed
Study type	Observational
Enrollment	2359 (Actual)
Sponsor	Procter and Gamble (Industry)
Conditions	Dental Plaque
Interventions	Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice (Drug)
Dates	start 2018-01-08, primary completion 2018-11-30, completion 2018-11-30, first posted 2019-07-05, last updated 2023-11-18
Locations	1 site in United States

-Summary

The aim of this 18 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices when used up to 3 months on dental plaque relative to a positive or negative control dentifrice.

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+Arms and interventions

Arm	Interventions	Description
Stannous Fluoride Dentifrice	Drug: Stannous fluoride dentifrice	Twice daily brushing
Positive control dentifrice	Drug: Positive control dentifrice	Twice daily brushing
Negative control dentifrice	Drug: Negative control dentifrice	Twice daily brushing

Stannous fluoride dentifrice (Drug): Stannous fluoride (0.454%) dentifrice
Positive control dentifrice (Drug): Positive control dentifrice containing (0.3%) triclosan.
Negative control dentifrice (Drug): Negative control dentifrice containing either sodium fluoride (0.243%) or sodium monofluorophosphate (0.76%)

+Outcome measures

Primary outcomes

Dental Plaque Scores [Up to 12 weeks]: Change from baseline as measured by mean plaque score reduction from baseline (via Quigley-Hein, Turesky Modification Index or Rustogi Modification of the Navy Plaque index).

+Eligibility

Sex: All, ages: 18 Years to any

Subjects were excluded from this study for the following reasons;

* pregnancy,
* rampant caries,
* severe periodontitis,
* at discretionary of the Principal Investigator.

+Locations (1)

Facility	City	Country	Status
Multiple P&G Investigation Clinical Sites	Cincinnati, Ohio	United States

My Notes

Public

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