Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia

NCT03943719 — Completed, 139 participants, Cliniques universitaires Saint-Luc- Université Catholique de Louvain

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The Impact of a Rapid Molecular Identification Test on Positive Blood Cultures From Critically Ill With Bacteremia: a Pre-post Intervention Study

RegistryNCT03943719, acronym SEPSIS2016
StatusCompleted
Study typeObservational
Enrollment139 (Actual)
SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain (Other); collaborators: BioMérieux
ConditionsSepticemia
InterventionsFilmArray blood culture identification panel (Diagnostic test)
Datesstart 2017-03-01, primary completion 2017-12-31, completion 2018-08-31, first posted 2019-05-09, last updated 2019-05-09
Locations1 site in Belgium

Related Papers Related Patents Related Grants Related Experts
All trials for Septicemia All trials of FilmArray blood culture identification panel

-Summary

Molecular testing is a largely validated approach allowing rapid identification of positive blood cultures. However, due to its high cost and its limited information on susceptibility, it is considered as an add-on technique reserved for specific patient populations. In our study, we specifically evaluated molecular testing in a critical care setting and measured its impact on the therapeutic management of critically ill with positive blood cultures. Through the analysis of 110 positive blood culture episodes included in both pre- and post intervention period, we measured a drastic 14h-reduction of the time to administration of the optimal antimicrobial treatment with the use of the molecular approach.

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+Arms and interventions

  • FilmArray blood culture identification panel (Diagnostic test): FilmArray blood culture identification panel is performed 24 hours on 24hours and 7 days a week on positive blood cultures to accelerate pathogens detection

+Outcome measures

Primary outcomes

  • Turn Around Time to optimal treatment of septicemia [From positivity detection of positive blood culture to administration of optimal treatment (up to 48 hours)]: Time in minutes

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* adult intensive care unit patients with positive blood cultures

Exclusion Criteria:

* palliative care patients

+Locations (1)

FacilityCityCountryStatus
Cliniques universitaires St-LucBrusselsBelgium

+Investigators

  • Alexia VERROKEN, Principal investigator, Cliniques universitaires St-Luc