Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma

NCT03754192 — Not applicable, Unknown, 50 participants, Assistance Publique - Hôpitaux de Paris

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Prediction Value of Perfusion and Dual Energy Computer Tomography for Microvascular Invasion in Hepatocellular Carcinoma

Registry	NCT03754192, acronym PERCAHEC
Status	Unknown
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, diagnostic
Enrollment	50 (Estimated)
Sponsor	Assistance Publique - Hôpitaux de Paris (Other)
Conditions	Hepatocellular Carcinoma
Interventions	perfusion Computed Tomography (Radiation)
Dates	start 2019-01-30, primary completion 2020-12-30 (estimated), completion 2020-12-30 (estimated), first posted 2018-11-27, last updated 2020-09-01
Locations	1 site in France

-Summary

The aim of this study is to evaluate the hepatic perfusion computer tomography and dual energy computer tomography in the assessment of tumor characterization of Hepatocellular carcinoma in patients with resectable Hepatocellular carcinoma by comparing the quantitative parameters computer tomography obtained with the pathological data of the surgical specimens.

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+Detailed description

Dual-energy computer tomography and perfusion computer tomography (General Electric revolution Hight definition Gemstone™ Spectral Imaging) will be performed in all patients. Iodine concentration and quantitative perfusion parameters of the Hepatocellular carcinoma and surrounding liver parenchyma data will be compared with the pathological results.

+Arms and interventions

Arm	Type	Interventions	Description
perfusion computed tomography	Other	Radiation: perfusion Computed Tomography	Will be realsed before liver surgery

perfusion Computed Tomography (Radiation), also known as Computed tomography: Will be carried before liver surgery

+Outcome measures

Primary outcomes

Pefusion parameters [5 minutes]: correlation between pre-operative imaging data and histological data of Hepatocellular carcinoma

Secondary outcomes

Pathological examination [1 month]: Compare data obtained in perfusion computer tomography to the imaging data and to the Histological differentiation grades

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* A diagnosis of Hepatocellular carcinoma made according to the guidelines of the American Association for the study of the Liver
* Affiliation to a national health insurance
* An indication for hepatic resection during the decision-making stage
* A request for a pre-operative Computer Tomography in our radiology unit
* An affiliation to a social security
* Informed consent given by the patient

Exclusion Criteria:

* Previous treatments of Hepatocellular carcinoma (medicated or surgical)
* Patient under tutorship or curatorship
* Pregnant or lactating woman

+Locations (1)

Facility	City	Country	Status
CHU Paul Brousse	Villejuif	France	Recruiting

+Publications

Results publication: Lewin M, Laurent-Bellue A, Desterke C, Radu A, Feghali JA, Farah J, Agostini H, Nault JC, Vibert E, Guettier C. Evaluation of perfusion CT and dual-energy CT for predicting microvascular invasion of hepatocellular carcinoma. Abdom Radiol (NY). 2022 Jun;47(6):2115-2127. doi: 10.1007/s00261-022-03511-7. Epub 2022 Apr 13. PMID 35419748

+Investigators

LEWIN MAITE, MD, PhD, Principal investigator, APHP

My Notes

Public

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