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Heated Circuit for One-lung Ventilation

NCT03649386 — Not applicable, Unknown, 104 participants, Keimyung University Dongsan Medical Center
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Effect of Heated-humidified Circuit on Arterial Oxygenation in Patients Undergoing One-lung Ventilation for Thoracoscopic Surgery

RegistryNCT03649386
StatusUnknown
PhaseNot applicable
Study typeInterventional; randomized, parallel, masking: triple, supportive care
Enrollment104 (Estimated)
SponsorKeimyung University Dongsan Medical Center (Other)
ConditionsOne-lung Ventilation, Oxygenation, Temperature
InterventionsHeated and humidified breathing circuit on, Heated and humidified breathing circuit off (Device)
Datesstart 2018-09-01 (estimated), primary completion 2019-09-01 (estimated), completion 2019-12-01 (estimated), first posted 2018-08-28, last updated 2018-08-28

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-Summary

One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.

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+Arms and interventions

ArmTypeInterventionsDescription
ControlActive comparatorDevice: Heated and humidified breathing circuit offHeated breathing circuit will turned off.
HeatExperimentalDevice: Heated and humidified breathing circuit onHeated breathing circuit will be turned on.
  • Heated and humidified breathing circuit on (Device): Heated and humidified breathing circuit will be turned on.
  • Heated and humidified breathing circuit off (Device): Heated and humidified breathing circuit will be turned off.

+Outcome measures

Primary outcomes

  • Arterial oxygenation [At 30 minutes after one-lung ventilation]: Arterial oxygenation (mmHg) will be measured by arterial blood analysis.

Secondary outcomes

  • Arterial oxygenation [At 0, 15, 45, and 60 minutes after one-lung ventilation]: Arterial oxygenation (mmHg) will be measured by arterial blood analysis.
  • Mean arterial pressure [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Mean arterial pressure (mmHg) will be measured.
  • Heart rate [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Heart rate (beats/min) will be measured.
  • Temperature [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Body temperature (°C) will be measured.
  • Central venous pressure [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Mean central venous pressure (mmHg) will be measured by a central venous catheter.
  • Cardiac index [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Cardiac index (l/min/m\^2) will be measured by pulse-contour analysis.
  • Pressure peak [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Peak pressure of ventilation (cmH2O) will be measured.
  • Pressure plateau [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Plateau pressure of ventilation (cmH2O) will be measured.
  • Arterial carbon dioxide [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Arterial carbon dioxide will be measured.
  • Arterial blood acidosis [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Arterial blood acidosis will be measured.
  • Oxygen saturation of arterial blood [At 0, 15, 30, 45, and 60 minutes after one-lung ventilation]: Oxygen saturation of arterial blood (%) will be measured.

+Eligibility

Sex: All, ages: 19 Years to 80 Years

Inclusion Criteria:

* American Society of Anesthesiologist class I-II
* Patients scheduled for one-lung ventilation for thoracoscopic surgery

Exclusion Criteria:

* Obesity
* Severe obstructive or restrictive lung disease
* Preoperative oxygen supply
* Preoperative intubated state or under mechanical ventilatory support
* Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg
* Symptomatic coronary or peripheral arterial disease
* Renal failure
* Preoperative continuous infusion of inotropes or vasopressor
* Pregnancy

+Investigators

My Notes