Does Mixing Alcoholic Drinks Make Hangover Worse? A Randomized Controlled Trial in a Naturalistic Setting
| Registry | NCT03506516 |
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| Status | Completed |
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| Phase | Not applicable |
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| Study type | Interventional; randomized, parallel, masking: triple, health services research |
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| Enrollment | 35 (Actual) |
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| Sponsor | Zealand University Hospital (Other) |
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| Conditions | Alcohol-Related Disorders |
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| Interventions | Mixing alcohol, Single type alcohol (Dietary supplement) |
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| Dates | start 2016-05-20, primary completion 2016-05-30, completion 2018-01-31, first posted 2018-04-24, last updated 2018-04-24 |
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-Summary
Does mixing alcohol make hangover worse?
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+Detailed description
Hangover is the most commonly occurring morbidity associated with heavy drinking.
Our aim was to test the hypothesis that mixing alcoholic drinks as compared to drinking one type of alcohol only (beer, wine or spirits) associate with a higher alcohol intake and worse hangover.
+Arms and interventions
| Arm | Type | Interventions | Description |
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| single type | Experimental | Dietary Supplement: Single type alcohol | Restricted to drinking only one type of alcohol |
| mixed type | Active comparator | Dietary Supplement: Mixing alcohol | Drinking and mixing different types of alcohols freely |
- Mixing alcohol (Dietary supplement), also known as Ethanol: Alcoholic beverages, different types
- Single type alcohol (Dietary supplement), also known as Ethanol: Alcoholic beverages, different types
+Outcome measures
Primary outcomes
- Acute Hangover Severity Scale (AHSS) [Baseline]: AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after.
Secondary outcomes
- Number of drinks [Baseline]: Total number of drinks defined as 12 g of alcohol consumed during evening
- Acute Hangover Severity Scale (AHSS) 2 [after 4 hours]: AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after.
- Acute Hangover Severity Scale (AHSS) 3 [after 8 hours]: AHSS is a 12-item alcohol hangover measurement tool recommended for application in hangover research with a predictive validity of 92.4 %, significantly higher than that of other hangover scales (Penning et al., 2012). Alcohol hangover was measured thrice the day after drinking; in the morning immediately after waking up, at midday, and in the afternoon. The individual participant assessed his or her own hangover the day after.
+Eligibility
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria:
* written and oral consent
* minimum 18 years old
* participating in Danish Health Research Retreat in Turkey 2016
* will consume alcoholic beverages
Exclusion Criteria:
* underage
* will not consume alcoholic beverages
+Investigators