The Analgesic Efficacy of the Ultrasound-Guided Femoral Articular Branch Block for Ambulatory Hip Arthroscopy: A Randomized-Controlled Trial
| Registry | NCT03449680 |
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, parallel, masking: triple, treatment |
| Enrollment | 94 (Actual) |
| Sponsor | Women's College Hospital (Other) |
| Conditions | Anesthesia, Regional |
| Interventions | Femoral Articular Branch Block, Placebo Block (Procedure) |
| Dates | start 2018-03-04, primary completion 2025-01-31, completion 2025-03-01, first posted 2018-02-28, last updated 2025-04-01 |
| Locations | 1 site in Canada |
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-Summary
Hip arthroscopy surgery can be associated with significant pain. A regional anesthesia technique, the femoral articular branch block (FAB), has recently been proposed to collectively block terminal femoral and accessory obturator nerve branches to the hip joint with a single injection, theoretically blocking most of the innervation relevant to hip arthroscopy while sparing the main femoral nerve branches to the quadriceps muscles. The investigators aim to demonstrate the analgesic benefits of FAB. The investigators hypothesize that FAB will reduce opioid consumption and improve postoperative quality of recovery in patients having hip arthroscopy. This is a randomized, controlled, double-blind study and half the patients will be randomized to receive the femoral articular branch block and the other half of patients will be randomized to receive a placebo block. A comparison of pain will be made between both groups.
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+Detailed description
Hip arthroscopy is a surgical technique that is gaining popularity for its diagnostic and therapeutic role in the management of adult hip pain. This procedure is frequently associated with severe post-operative pain despite the practice of injecting the hip joint with local anesthetics at the end of the procedure and the use of intraoperative opioids. The ideal analgesic technique that provides adequate pain relief following this procedure has not been established yet.
There is evidence to suggest that a femoral nerve block (FNB) may provide clinically meaningful analgesia. The investigators have examined the benefits of FNB both retrospectively and prospectively in hip arthroscopy patients at Women's College Hospital (WCH). Both of our studies suggested modest benefits of the FNB in terms of controlling post-operative pain and reducing opioid consumption. However the majority of patients continued to experience moderate to severe post-operative pain and required significant amounts of opioid analgesics in the Peri-Anesthesia Unit (PAU), despite receiving the FNB.
Another regional anesthesia technique, the femoral articular branch block (FAB) has recently been proposed to collectively block the terminal femoral and accessory obturator nerve branches to the hip joint with a single injection, theoretically blocking most of the innervation relevant to hip arthroscopy while sparing the main femoral nerve branches to the quadriceps muscle. The investigators aim to demonstrate the analgesic benefits of FAB.
+Arms and interventions
| Arm | Type | Interventions | Description |
|---|
| Femoral Articular Branch Block | Experimental | Procedure: Femoral Articular Branch Block | Patients will receive an ultrasound-guided femoral articular branch block with an injection of 20ml of ropivicaine 0.5% |
| Placebo Block | Placebo comparator | Procedure: Placebo Block | Patients will receive an ultrasound simulation of the location of a femoral articular branch block , this is to maintain blinding. A subcutaneous injection of 1ml of normal sterile saline will be administered |
- Femoral Articular Branch Block (Procedure): Slow injection (3mL aliquots) of local anesthetic solution (20ml of Ropivacaine 0.5%) into the fascia above the iliopsoas muscle (located in the groove between the two bony landmarks - (1)anterior inferior iliac crest and (2)iliopubic eminence).This is done by ultrasound guidance.
- Placebo Block (Procedure): Subcutaneous injection of 1ml normal sterile saline
+Outcome measures
Primary outcomes
- Analgesic Consumption [24 hours postoperatively]: Postoperative cumulative oral morphine equivalent consumption during the first 24 hours will be the first primary outcome
- Quality of Life scores [24 hours postoperatively]: Quality of Recovery (QR15) scores at 24 hours will be the second primary outcome.
QR15 is a measurement of quality of recovery after surgery and anesthesia that has been psychometrically tested and validated. Reporting of outcome measures on a scale of 0 to 10 (0=None of the time and 10=All of the time). There are a total of 40 items/questions.
Secondary outcomes
- Pain Assessment (VAS) [Up to 48 hours post-operatively and at 7-day mark]: Visual Analogue Scale(VAS) - Pain:Overall pain assessed at rest and on movement A continuous scale comprised of a 100mm (10cm) horizontal line, anchored by 2 verbal descriptions No Pain to Worst Pain
- Analgesic Consumption [Up to 48 hours following surgery]: Consumption intra-operatively, total in-hospital postoperative consumption, and time to first analgesic request in the first 24 hours, cumulative oral morphine equivalent
- Presence of Block-related complications [Up until one month following nerve block]: vascular puncture, hematoma formation, intravascular injection, epidural anesthesia-bilateral sensory block Presence/ absence of residual paresthesia or numbness over femoral, obturator, and lateral cutaneous nerves distribution
- Incidence of opioid-related side effects [Up until one month following nerve block]: nausea, vomiting, pruritus, sedation
- Patient Satisfaction with Analgesic Technique [One month after surgery]: A Patient Diary will be completed to assess overall satisfaction with analgesic technique
- Demographic Data [Day 1 - first 24 hours]: Patient demographics - There is no scale, just questions asked of the participant.
- Turn over time [after surgery up to discharge, assessed up to 24 hours]: PAU leaving time
+Eligibility
Sex: All, ages: 18 Years to 60 Years
Inclusion Criteria:
* American Society of Anesthesiologists (ASA) physical classification system, ASA I-III patients
* 18 - 60 years of age
* Body Mass Index (BMI) <35 kg/m2
Exclusion Criteria:
* Pre-existing neurological deficits or peripheral neuropathy in the distribution of femoral, obturator, or lateral cutaneous nerves
* Local infection
* Contra-indication to regional anesthesia e.g. bleeding diathesis, coagulopathy
* Chronic pain disorders
* History of using over 30mg of oxycodone or equivalent per day
* Contraindication to a component of multi-modal analgesia
* Allergy to local anesthesia
* History of significant psychiatric conditions that may affect patient assessment
* Pregnancy
* Inability to provide informed consent
* Patient refusal of femoral articular branch block
* Revision arthroscopy surgeries
+Locations (1)
| Facility | City | Country | Status |
|---|
| Women's College Hospital | Toronto, Ontario | Canada | |
+Publications
- Short AJ, Barnett JJG, Gofeld M, Baig E, Lam K, Agur AMR, Peng PWH. Anatomic Study of Innervation of the Anterior Hip Capsule: Implication for Image-Guided Intervention. Reg Anesth Pain Med. 2018 Feb;43(2):186-192. doi: 10.1097/AAP.0000000000000701. PMID 29140962
- Results publication: Suzuki S, Awaya G, Okada Y, Maekawa M, Ikeda T, Tada H. Arthroscopic diagnosis of ruptured acetabular labrum. Acta Orthop Scand. 1986 Dec;57(6):513-5. doi: 10.3109/17453678609014781. PMID 3577718
- Results publication: Larson CM, Swaringen J, Morrison G. A review of hip arthroscopy and its role in the management of adult hip pain. Iowa Orthop J. 2005;25:172-9. PMID 16089093
- Results publication: Baber YF, Robinson AH, Villar RN. Is diagnostic arthroscopy of the hip worthwhile? A prospective review of 328 adults investigated for hip pain. J Bone Joint Surg Br. 1999 Jul;81(4):600-3. doi: 10.1302/0301-620x.81b4.8803. PMID 10463728
- Results publication: Lee EM, Murphy KP, Ben-David B. Postoperative analgesia for hip arthroscopy: combined L1 and L2 paravertebral blocks. J Clin Anesth. 2008 Sep;20(6):462-5. doi: 10.1016/j.jclinane.2008.04.012. PMID 18929290
- Results publication: Baker JF, Byrne DP, Hunter K, Mulhall KJ. Post-operative opiate requirements after hip arthroscopy. Knee Surg Sports Traumatol Arthrosc. 2011 Aug;19(8):1399-402. doi: 10.1007/s00167-010-1248-4. Epub 2010 Sep 9. PMID 20827460
- Results publication: Ward JP, Albert DB, Altman R, Goldstein RY, Cuff G, Youm T. Are femoral nerve blocks effective for early postoperative pain management after hip arthroscopy? Arthroscopy. 2012 Aug;28(8):1064-9. doi: 10.1016/j.arthro.2012.01.003. Epub 2012 Apr 11. PMID 22498045
- Results publication: Dold AP, Murnaghan L, Xing J, Abdallah FW, Brull R, Whelan DB. Preoperative femoral nerve block in hip arthroscopic surgery: a retrospective review of 108 consecutive cases. Am J Sports Med. 2014 Jan;42(1):144-9. doi: 10.1177/0363546513510392. Epub 2013 Nov 27. PMID 24284048
- Results publication: Xing JG, Abdallah FW, Brull R, Oldfield S, Dold A, Murnaghan ML, Whelan DB. Preoperative Femoral Nerve Block for Hip Arthroscopy: A Randomized, Triple-Masked Controlled Trial. Am J Sports Med. 2015 Nov;43(11):2680-7. doi: 10.1177/0363546515602468. Epub 2015 Sep 24. PMID 26403206
- Results publication: GARDNER E. The innervation of the hip joint. Anat Rec. 1948 Jul;101(3):353-71. doi: 10.1002/ar.1091010309. No abstract available. PMID 18873153
- Results publication: Dee R. Structure and function of hip joint innervation. Ann R Coll Surg Engl. 1969 Dec;45(6):357-74. No abstract available. PMID 5359432
- Results publication: Birnbaum K, Prescher A, Hessler S, Heller KD. The sensory innervation of the hip joint--an anatomical study. Surg Radiol Anat. 1997;19(6):371-5. doi: 10.1007/BF01628504. PMID 9479711
- Results publication: Tan JMH, Giron-Arango L, Campbell S, Diaz-Martinez JP, Abdallah F, Brull R. Analgesic efficacy of the ultrasound-guided pericapsular nerve group (PENG) block for ambulatory hip arthroscopy: a randomized controlled double-blind trial. Reg Anesth Pain Med. 2026 Mar 27:rapm-2026-107706. doi: 10.1136/rapm-2026-107706. Online ahead of print. PMID 41895809
+Investigators
- Richard Brull, MD, Principal investigator, Women's College Hospital, University of Toronto
- Daniel Whelan, MD, Principal investigator, Women's College Hospital, University of Toronto