Efficiency and Safety of Phenylephrine and Tropicamide Used in Premature Retinopathy
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All trials for Retinopathy of Prematurity All trials of Drug used in the examination of premature infants.
-Summary
Because of the neonatologists reported that some infants had suffered from vomiting, bradycardia, hypotonia, and aspiration risk about 30-60 minutes after the fundus examination in the intensive care unit. The investigators observed the pupil dilation effects and side effects of tipple instillation of phenylephrine 2.5% plus tropicamide 0.5% ophthalmic drop combination which the investigators routinely used in ROP examination.
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+Detailed description
Purpose: To determine effect and vital change after topical application of phenylephrine 2.5% and tropicamide 0.5% three times for retinopathy of prematurity (ROP) examination in preterm infants.
Methods: Pupillary diameter, blood pressure, pulse rate, and oxygen saturation were monitored before, and after up to 24 hours 60 ROP screening examinations.
+Arms and interventions
- Drug used in the examination of premature infants. (Drug), also known as Tropicamide and mydfline used: to investigate side effects of eye drops used
+Outcome measures
Primary outcomes
- The mean pupillary diameter [an average of 1 year]: will be measured with a ruler after 60 minutes instillation of mydriatic
+Eligibility
Sex: All, ages: 32 Weeks to 34 Weeks
Inclusion Criteria:
* Infants who were first ROP examinations
* infants born before 32 weeks.
Exclusion Criteria:
* Developmental ocular and/or systemic anomalies.
* Drug use that can affect vital values
* Unstable general condition
* Food intolerance
* Recurrent vomiting.
+Publications
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