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Metabolism and the Activity of the Autonomic Nervous System in Patients With Paroxystic Sympathetic Hyperactivity, PSH

NCT03441009 — Completed, 15 participants, Region MidtJylland Denmark
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RegistryNCT03441009, acronym MANS-PSH
StatusCompleted
Study typeObservational
Enrollment15 (Actual)
SponsorRegion MidtJylland Denmark (Other)
ConditionsAutonomic Nervous System Imbalance
InterventionsPhysio-/occupational therapy (Other)
Datesstart 2016-01-02, primary completion 2020-10-01, completion 2020-10-01, first posted 2018-02-22, last updated 2021-09-24

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-Summary

Adult patients suffering from acquired brain damage run the risk of developing PSH. This group of patients is admitted to our unit, the Neurointensive Stepdown Unit, at Silkeborg Regional Hospital for intensive care and early neurorehabilitation. After weaning from intensive carethey are transferred to Hammel NeuroCentre.

Aim is to assess whether HRV-derived variables in the frequency domain mirror therapeutic and/or nursing and/or pharmacologic interventions. To the extent clinically available BRS and metabolism are included in the assessment.

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+Detailed description

See report:

Honore H, Eggertsen K, Sondergaard S: A study into the feasibility of using HRV variables to guide treatment in patients with paroxystic sympathetic hyperactivity in a neurointensive step-down unit. NeuroRehabilitation 2019, 44(1):141-155.

+Arms and interventions

  • Physio-/occupational therapy (Other), also known as Psycotropic medications: Physio-/occupational therapy, ADL

+Outcome measures

Primary outcomes

  • Difference before vs after intervention in frequency domain parameters of HRV [immediate]: HRV parameters: low frequency (LF, 0.04-0.15 Hz), high frequency (HF, 0.15-0.4 Hz) in terms of peak frequency (Hz), absolute power (ms2, natural logarithm transformed values of absolute powers of VLF, LF, and HF bands), relative power (absolute power/total power), normalized power (%, normalized units, n.u.), total power given by VLF + HF + LF (ms2) and LF/HF ratio.
  • Qualitative description expressed as goal attainment scaling (GAS) of therapeutic interventions [immediate]: Two independent ratings on a 5-point scale, -2 to +2

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

Symptoms of PSH according to Baguley scoring table

Exclusion Criteria:

No symptoms of PSH

+Investigators

  • Jørgen Feldbæk, Professor, Study chair, Hammel Neuro- and Research Centre

My Notes