Legionnaires' Effect on Smell

NCT03321786 — Completed, 10 participants, University of Pennsylvania

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Legionella Pneumonia's Effect on Olfactory Function

Registry	NCT03321786
Status	Completed
Study type	Observational
Enrollment	10 (Actual)
Sponsor	University of Pennsylvania (Other)
Conditions	Legionnaires' Disease
Interventions	The University of Pennsylvania Smell Identification Test (UPSIT) (Other)
Dates	start 2017-09-06, primary completion 2024-06-15, completion 2024-06-15, first posted 2017-10-26, last updated 2024-07-24
Locations	1 site in United States

-Summary

The goal of this study is to determine whether survivors of Legionnaires' disease suffer smell loss. A quantitative olfactory test will be performed by the participants. Such testing will require approximately 20-30 minutes of the participant's time. The participants will take the University of Pennsylvania Smell Identification Test (UPSIT), a scratch-and-sniff test to assess their ability to identify odors in a forced- choice format. Volunteers will also complete a questionnaire asking personal history, demographic questions, and medical history.

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+Arms and interventions

Arm	Type	Interventions	Description
Legionnaires' Disease Volunteers		Other: The University of Pennsylvania Smell Identification Test (UPSIT)	Volunteers who have been diagnosed/survivors of Legionnaire's Disease
Healthy Volunteers		Other: The University of Pennsylvania Smell Identification Test (UPSIT)	Volunteers who are healthy.

The University of Pennsylvania Smell Identification Test (UPSIT) (Other): This standardized test, the most widely used olfactory test in the world, is derived from basic psychological test measurement theory and focuses on the comparative ability of subjects to identify odorants at the suprathreshold level. The UPSIT consists of four envelope-sized booklets, each containing ten "scratch and sniff" odorants embedded in 10- 50-µm polymer microcapsules positioned on brown strips at the bottom of the pages of the booklets.

+Outcome measures

Primary outcomes

Score on the University of Pennsylvania Smell Identification Test [20-30 Minutes]: The number of correct odor identification responses out of 40 from the standardized University of Pennsylvania Smell Identification Test. The total number of correct responses will then be compared to standard norms of correct responses based on demographic information such as age and sex. Comparing the scores to the standard norms collected will indicate whether a volunteer is normosmic, hyposmic, or anosmic.

Secondary outcomes

Questionnaire Responses [20-30 Minutes]: These are various demographic and medical history questions regarding exposure to Legionella Pneumonia and current experiences post diagnosis and treatment.

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Persons of generally good health, as obtained from a screening questionnaire who are 18 years of age and older
* Both men and women of all ethnic backgrounds will be accepted.

Exclusion Criteria:

* Age less than 18
* Pregnant Women
* Persons who mental competence is limited, such as those with dementia

+Locations (1)

Facility	City	Country	Status
University of Pennsylvania	Philadelphia, Pennsylvania	United States

+Investigators

Richard L Doty, PhD, Principal investigator, University of Pennsylvania

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