Cardiovascular Effects of Ultramarathon Running
| Registry | NCT03304483, acronym Spartathlon |
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| Status | Completed |
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| Phase | Not applicable |
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| Study type | Interventional; na, single group, masking: none, screening |
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| Enrollment | 50 (Actual) |
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| Sponsor | Aristotle University Of Thessaloniki (Other) |
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| Conditions | Disorder Heart |
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| Interventions | 246-km running (Other) |
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| Dates | start 2017-09-29, primary completion 2019-12-30, completion 2021-06-30, first posted 2017-10-09, last updated 2023-07-20 |
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| Locations | 1 site in Greece |
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-Summary
The aim of this study is to examine the cardiovascular effects of ultramarathon running and their relation to performance.
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+Detailed description
The purpose of the study is to determine the changes of cardiovascular morphology and function after an ultramarathon race. 50 entrants to the "Spartathlon 2017" 246-km running race will participate in the study. Cardiac and arterial morphology and function tests will be conducted one day before the race and within 20 minutes of race completion.
+Arms and interventions
| Arm | Type | Interventions | Description |
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| Athletes | Experimental | Other: 246-km running | 246-km running |
- 246-km running (Other): Spartathlon 2017
+Outcome measures
Primary outcomes
- Change of right ventricular function after one day ultra-marathon running [before and after 1 day running]: Echocardiographic study of left ventricular function
Secondary outcomes
- Change of left ventricular function after one day ultra-marathon running [before and after 1 day running]: Echocardiographic study of left ventricular function
- Change of carotid artery function after one day ultra-marathon running [before and after 1 day running]: Echocardiographic study of carotid arteries
+Eligibility
Sex: All, ages: 18 Years to 67 Years, accepts healthy volunteers
Inclusion Criteria:
* Runners at least 18 years old, healthy and sufficiently trained.
* Runners being accepted to participate in the Spartathlon race according to the eligibility criteria (http://www.spartathlon.gr/en/registration-en.html)
* Runners who will volunteer to be examined pre- and post the race
Exclusion Criteria:
* Runners with chronic diseases
* Runners receiving any medication
+Locations (1)
| Facility | City | Country | Status |
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| Laboratory of Sports Medicine | Thessaloniki | Greece | |
+Publications
- Seedhouse EL, Walsh ML, Blaber AP. Heart rate, mean arterial blood pressure, and pulmonary function changes associated with an ultraendurance triathlon. Wilderness Environ Med. 2006 Winter;17(4):240-5. doi: 10.1580/pr27-05-r1.1. PMID 17219787
- Millet GP, Millet GY. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC Med. 2012 Jul 19;10:77. doi: 10.1186/1741-7015-10-77. PMID 22812424
- Cote AT, Phillips AA, Foulds HJ, Charlesworth SA, Bredin SS, Burr JF, Koehle MS, Warburton DE. Sex differences in cardiac function after prolonged strenuous exercise. Clin J Sport Med. 2015 May;25(3):276-83. doi: 10.1097/JSM.0000000000000130. PMID 25010150
- Jee H, Park J, Oh JG, Lee YH, Shin KA, Kim YJ. Effect of a prolonged endurance marathon on vascular endothelial and inflammation markers in runners with exercise-induced hypertension. Am J Phys Med Rehabil. 2013 Jun;92(6):513-22. doi: 10.1097/PHM.0b013e31829232db. PMID 23685440
- Results publication: Blaber AP, Walsh ML, Carter JB, Seedhouse EL, Walker VE. Cardiopulmonary physiology and responses of ultramarathon athletes to prolonged exercise. Can J Appl Physiol. 2004 Oct;29(5):544-63. doi: 10.1139/h04-035. PMID 15507692
+Investigators