Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases

The postmenopausal women with vaginal bleeding are selected in this cross-sectional study. The uterine bleeding in patients with blood system diseases, reproductive organ outside the uterus, other organs cancer metastasis to the uterus are excluded. The objects are divided into two groups(patients with endometrial benign diseases and patients with endometrial cancer and precancerous diseases) according to endometrial cytological and histological pathology. The endometrial thickness, basic characteristics information and endometrial blood flow energy index, endometrial vascularization index, blood flow index are detected by color power Doppler and the energy histogram of endometrium is obtained using a Voluson E8 (GE Medical Systems, USA) ultrasound system. Moreover,The specimen of uterine cytology and endometrial tissue are obtained through minimally invasive endometrium sampler, which were diagnosed by pathology.

• Voluson E8 (GE Medical Systems, USA), Minimally Invasive Endometrium Sampler (Diagnostic test): The endometrial thickness, basic characteristics information and endometrial blood flow energy index, endometrial vascularization index, blood flow index are detected by color power Doppler and the energy histogram of endometrium is obtained using a Voluson E8 (GE Medical Systems, USA) ultrasound system. The specimen of uterine cytology and endometrial tissue are obtained through minimally invasive endometrium sampler, which are diagnosed by pathology.

Primary outcomes

• The endometrial vascularization index [From March 2019 to December 2019]: The endometrial vascularization index include vascularization index(VI), flow index (FI) and vascularization flow index (VFI).

Secondary outcomes

• The ultrasonography of endometrium [From March 2019 to December 2019]: The ultrasonography of endometrium included shape, boundary and echo.
• The endometrial thickness [From March 2019 to December 2019]: The endometrial thickness in centimeter.
• The blood flow index of endometrium [From March 2019 to December 2019]: The blood flow index include peak systolic velocity(PSV),cm/s, end diastolic velocity(EDV) ,cm/s, mean flow velocity(MnV) ,cm/s, pulsatility index(PI), resistance index(RI).

Sex: Female, ages: 45 Years to 80 Years

Inclusion Criteria:

* Postmenopausal women with vaginal bleeding

Exclusion Criteria:

* Vaginal bleeding caused by hematological system diseases or genitals outside the uterus
* Uterine bleeding caused by other organ cancers metastasize to the uterus

• Xiaofeng YANG, Doctor, Study director, First Affiliated Hospital Xi'an Jiaotong University