Genomic Assessment of Patients With Severe Radiation Reactions

Registry	NCT03287349
Status	Completed
Study type	Observational
Enrollment	3 (Actual)
Sponsor	Mayo Clinic (Other)
Conditions	Radiation; Reaction
Interventions	Blood draw, Photograph, Autoimmune testing (Other, diagnostic test)
Dates	start 2017-05-10, primary completion 2023-01-04, completion 2023-01-04, first posted 2017-09-19, last updated 2024-11-15
Locations	1 site in United States

-Summary

Determine an underlying etiology behind unexpectedly severe reactions to radiation by blood draw.

Arm	Type	Interventions	Description
Patients with severe reactions to radiation		Other: Blood draw; Other: Photograph; Diagnostic Test: Autoimmune testing	Two 12.5 mL blood draws and photograph of severe reaction, and autoimmune testing in patients without prior testing.

Blood draw (Other): Two 12.5 mL blood draws
Photograph (Other): Photograph of severe reaction, will be anonymized
Autoimmune testing (Diagnostic test): Autoimmune testing in patients without prior testing

Whole exome sequencing [baseline]: Investigate genes potentially responsible for severe radiation reactions by getting blood draws.

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Weigh at least 110 pounds
* Healthy

Exclusion Criteria:

\- Pregnant

Facility	City	Country	Status
Mayo Clinic in Rochester	Rochester, Minnesota	United States

Public

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