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Effect of Anesthesia on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Prostatectomy

NCT03271502 — Not applicable, Completed, 36 participants, Asan Medical Center

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Effect of Inhalation Anesthesia With Sevoflurane and Total Intravenous Anesthesia With Propofol on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Prostatectomy

RegistryNCT03271502
StatusCompleted
PhaseNot applicable
Study typeInterventional; randomized, parallel, masking: quadruple, other
Enrollment36 (Actual)
SponsorAsan Medical Center (Other)
ConditionsProstate Cancer
InterventionsTotal intravenous anesthesia, Inhalation anesthesia (Procedure)
Datesstart 2017-09-04, primary completion 2017-09-26, completion 2017-10-01, first posted 2017-09-05, last updated 2017-10-26
Locations1 site in South Korea

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-Summary

The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during total intravenous anesthesia and the optic nerve sheath diameter measured during inhalation anesthesia in patients undergoing robot-assisted laparoscopic prostatectomy.

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+Detailed description

The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during total intravenous anesthesia with propofol and remifentanil and the optic nerve sheath diameter measured during inhalation anesthesia with sevoflurane and remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

+Arms and interventions

ArmTypeInterventionsDescription
Total intravenous anesthesiaExperimentalProcedure: Total intravenous anesthesiaTotal intravenous anesthesia with propofol and remifentanil
Inhalation anesthesiaActive comparatorProcedure: Inhalation anesthesiaInhalation anesthesia with sevoflurane and remifentanil
  • Total intravenous anesthesia (Procedure): Total intravenous anesthesia with propofol and remifentanil
  • Inhalation anesthesia (Procedure): Inhalation anesthesia with sevoflurane and remifentanil

+Outcome measures

Primary outcomes

  • Difference in optic nerve sheath diameter [60 minutes after pneumoperitoneum and steep Trendelenburg position]: Difference between the optic nerve sheath diameter measured during total intravenous anesthesia and the optic nerve sheath diameter measured during inhalation anesthesia

Secondary outcomes

  • Difference in optic nerve sheath diameter [30 minutes after pneumoperitoneum and steep Trendelenburg position]: Difference between the optic nerve sheath diameter measured during total intravenous anesthesia and the optic nerve sheath diameter measured during inhalation anesthesia
  • Difference in optic nerve sheath diameter [5 minutes after pneumoperitoneum and steep Trendelenburg position]: Difference between the optic nerve sheath diameter measured during total intravenous anesthesia and the optic nerve sheath diameter measured during inhalation anesthesia

+Eligibility

Sex: Male, ages: 20 Years to 79 Years

Inclusion Criteria:

Patients who have undergone a robot-assisted laparoscopic prostatectomy with a prostate cancer and who are 20 years of age or older and under 80 years of age and who agree to participate in this study.

Exclusion Criteria:

Patients with a history of cerebral hemorrhage or cerebral infarction, Patients < 20 years of age, Patients ≥ 80 years of age, Patients with unexpected hemodynamic instability during surgery, Failure to measure optic nerve sheath diameter.

+Locations (1)

FacilityCityCountryStatus
Asan Medical CenterSeoulSouth Korea

+Publications

  • Results publication: Yu J, Hong JH, Park JY, Hwang JH, Cho SS, Kim YK. Propofol attenuates the increase of sonographic optic nerve sheath diameter during robot-assisted laparoscopic prostatectomy: a randomized clinical trial. BMC Anesthesiol. 2018 Jun 20;18(1):72. doi: 10.1186/s12871-018-0523-7. PMID 29925316

+Investigators

My Notes