Cerebral Infarction and White Substance in Angiopathy Cerebral Amyloid

NCT03262246 — Completed, 126 participants, Fondation Hôpital Saint-Joseph

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Registry	NCT03262246
Status	Completed
Study type	Observational
Enrollment	126 (Actual)
Sponsor	Fondation Hôpital Saint-Joseph (Other)
Conditions	Amyloid Angiopathy
Interventions	medical report consultation (Other)
Dates	start 2016-06-02, primary completion 2016-12-31, completion 2018-12-31, first posted 2017-08-25, last updated 2019-02-04
Locations	1 site in France

-Summary

The cerebral amyloïd angiopathy ( AAC) is a disease characterized by deposits of beta-amyloid peptids in the walls of the arteries of young and average calibre of the brain and the leptomeninx. The incidence of the AAC increases strongly with the age and represents a major cause of spontaneous brain haemorrhage to people over 60. The main demonstration is the lobar brain haemorrhage, the other ones are bleedings under arachnoid cortical and microbleedings leading to cognitive decline.

Anatomical studies reported the presence of cortical infarcts in patients having amyloïd deposits suggesting an association between asymptomatic cortical cerebral infarcts and AAC.

However prevalence and meaning of these infarcts in patients having an AAC remain badly known because of studies on low number of patients and the rarity of radiological analyses of these infarcts .A better knowledge of these asymptomatic cortical infarcts would allow to dread better cognitive disorders(confusions) presented by these patients, and to develop preventive strategies.

Besides, the risk factors of severity of the AAC are little studied.

Expand all sections · Collapse all

+Arms and interventions

medical report consultation (Other): investigators consult medical report concerning patient identified for cerebral amyloid angiopathy

+Outcome measures

Primary outcomes

number of patient with cerebral infarction and associated factors in a cohort of cerebral amyloid angiopathy patients [1day]

+Eligibility

Sex: All, ages: 55 Years to any

Inclusion Criteria:

* age>55
* hospitalized in CAEN hospital and Paris St Joseph Hospital between 1st january 2011 and 31 december 2015 for cerebral haemorrhage with MRI images diagnosing cerebral amyloid angiopathy.

Exclusion Criteria:

* Insufficient MRI images quality without FLAI sequence, T2 GRE
* disease with same radiologic and clinical signs that cerebral amyloid angiopathy.

+Locations (1)

Facility	City	Country	Status
Groupe Hospitalier Paris Saint Joseph	Paris, Île-de-France Region	France

+Investigators

HODEL Jérome, Professor, Principal investigator, GHPSJ