Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance

NCT03159065 — Not applicable, Completed, 12 participants, Lund University

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Early Postprandial Efficacy of Probiotic Fruit Beverages on Glucose Tolerance and Insulin Resistance in Healthy Adults

Registry	NCT03159065
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: quadruple, screening
Enrollment	12 (Actual)
Sponsor	Lund University (Other)
Conditions	Postprandial Hyperglycemia
Interventions	Bilberry, Blackcurrant, Mango, Beetroot, Rose hip, Glucose drink (Other)
Dates	start 2014-09-01, primary completion 2014-11-01, completion 2015-01-01, first posted 2017-05-18, last updated 2017-05-19

-Summary

Consumption of polyphenol-rich fruits and vegetables may improve the postprandial glucose and insulin responses and hence promote well-being. It has previously been observed that consumption of a bilberry drink decreases the postprandial insulin demand. In the present study, the impact of probiotic fruit beverages with different polyphenol profiles on the postprandial levels of glucose and insulin, were investigated.

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+Arms and interventions

Arm	Type	Interventions	Description
Bilberry	Experimental	Other: Bilberry	A bilberry-based beverage with fermented oatmeal
Blackcurrant	Experimental	Other: Blackcurrant	A blackcurrant-based beverage with fermented oatmeal
Mango	Experimental	Other: Mango	A mango-based based beverage with fermented oatmeal
Beetroot	Experimental	Other: Beetroot	A beetroot-based based beverage with fermented oatmeal
Rose hip	Experimental	Other: Rose hip	A rose hip-based based beverage with fermented oatmeal
Glucose drink	Active comparator	Other: Glucose drink	A reference glucose drink

Bilberry (Other): Fruit beverage with bilberry and fermented oatmeal
Blackcurrant (Other): Fruit beverage with blackcurrant and fermented oatmeal
Mango (Other): Fruit beverage with mango and fermented oatmeal
Beetroot (Other): Fruit beverage with beetroot and fermented oatmeal
Rose hip (Other): Fruit beverage with rose hip and fermented oatmeal
Glucose drink (Other): A reference glucose drink

+Outcome measures

Primary outcomes

Efficacy of the study products on the postprandial serum insulin [Incremental area under the curve for serum insulin from 0 min up to 120 min following the ingestion of the study product]: The postprandial incremental area under the curve for serum insulin

Secondary outcomes

Efficacy of the study products on the postprandial serum glucose [Incremental area under the curve for serum glucose from 0 min up to 120 min following the ingestion of the study product]: The postprandial incremental area under the curve for serum glucose

+Eligibility

Sex: All, ages: 18 Years to 65 Years, accepts healthy volunteers

Inclusion Criteria:

* Healthy, not on medication, non-allergic, individuals aged 18-65 years old, having a BMI between 20-30 kg/m2 and also maintaining stable body weight, i.e. less than 5% weight change in the last three months before the study.

Exclusion Criteria:

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+Publications

Results publication: Xu J, Jonsson T, Plaza M, Hakansson A, Antonsson M, Ahren IL, Turner C, Spegel P, Granfeldt Y. Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response. Nutr J. 2018 Feb 27;17(1):34. doi: 10.1186/s12937-018-0335-0. PMID 29486772

+Investigators

Yvonne Granfeldt, Prof, Study director, Lund University