Build-up of Action Representation in Autism Spectrum Disorders

NCT03108976 — Not applicable, Completed, 54 participants, Hospices Civils de Lyon

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Build-up of Action Representation During Neurodevelopment: Dysfunctions in Autism Spectrum Disorders?

Registry	NCT03108976, acronym ASD-BARN
Status	Completed
Phase	Not applicable
Study type	Interventional; non randomized, parallel, masking: none, basic science
Enrollment	54 (Actual)
Sponsor	Hospices Civils de Lyon (Other)
Conditions	Healthy, Autism Spectrum Disorder
Interventions	Behavioral assessments, Magnetoencephalography (MEG), Magnetic Resonance Imaging (MRI) (Other)
Dates	start 2015-04-10, primary completion 2018-12-31, completion 2018-12-31, first posted 2017-04-11, last updated 2022-08-26
Locations	1 site in France

-Summary

Autistic spectrum disorders (ASD) are highly debilitating developmental syndromes which core feature is social and communications disorders. Motor skill impairments are frequently described in autism, but few studies have addressed the question of their origin and their specificity. Furthermore, it is not clear whether motor problems encountered in autism are related to dyspraxia, or if they present with specific features. This project aims at deciphering the origin of motor problems encountered by children who grow-up with autism in order to propose early interventions that could influence the other developmental trajectories, such as the social one.

Brain dynamics during sensori-motor learning is explored by applying magnetoencephalography (MEG) during the Bimanual Load-Lifting paradigm. Different motor processes namely: proprioceptive monitoring, use and update of a sensori-motor representation, anticipatory executive control will be correlated to brain oscillation modulation, both topographically and temporally. Two groups of children (aged between 7 and 12) are compared: a group of children with ASD and a control group of typically developing children.

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+Arms and interventions

Arm	Type	Interventions	Description
Control group	Sham comparator	Other: Behavioral assessments; Other: Magnetoencephalography (MEG); Other: Magnetic Resonance Imaging (MRI)	Children with a typical development.
Case group	Active comparator	Other: Behavioral assessments; Other: Magnetoencephalography (MEG); Other: Magnetic Resonance Imaging (MRI)	Children with Autism Spectrum Disorders.

Behavioral assessments (Other): Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).
Magnetoencephalography (MEG) (Other): Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).
Magnetic Resonance Imaging (MRI) (Other): Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).

+Outcome measures

Primary outcomes

Changes of cerebral oscillations in three frequency bands (alpha, beta, gamma) during sensori-motor learning. [Day 1]: Oscillatory measures are computed in the sensor and source space in order to identify the regions involved in the sensori-motor learning in the control group and in the ASD group.

Secondary outcomes

Correlation between oscillatory measures and learning performance. [Day 1]: Kinematic recordings enable to measure the learning performance at the end of the experiment. This measure will be correlated with oscillatory changes during the task.

+Eligibility

Sex: All, ages: 7 Years to 12 Years, accepts healthy volunteers

Inclusion Criteria:

* Control group: children aged between 7 and 12
* Case group: children aged between 7 and 12 with a diagnostic of Autism Spectrum Disorders

Exclusion Criteria:

* Control group: presence of a neurological pathology, mental retardation or language and motor developmental delay
* Case group: presence of a neurological pathology, mental retardation

+Locations (1)

Facility	City	Country	Status
CH le Vinatier	Bron	France

+Investigators

Sandrine SONIE, MD, Principal investigator, CH le Vinatier

My Notes

Public

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