Effects of Dexmedetomidine on Patients With Coronary Heart Disease After Percutaneous Coronary Intervention

Participants will be randomly assigned, in a 1:1 ratio, to receive Dexmedetomidine or control (0.9 %Sodium Chloride Solution,0.9%NaCl). The randomization sequence will be computer-generated, and randomization will be performed in blocks and will be stratified according to participating center. Dexmedetomidine and 0.9 % NaCl solution will be transfused when the operation began, ending 24 hours after the surgery. Troponin I level(but are not limited to these data) at pre-operation and 3h, 6h,12h, 24h, 48h after PCI will be recorded. At the same time, other dates will be recorded.The participation of each patient is scheduled for 12 months.

• Dexmedetomidine (Drug), also known as Dexmedetomidine Injection: when the operation begin,dexmedetomidine will be pumped at 0.4μg/kg•h for 15 minutes ,then reduce the dose to 0.2μg/kg•h until 24h after PCI.
• 0.9%NaCl solution (Drug), also known as Other Name: normal saline: when the operation begin,0.9%NaCl solution will be pumped at 0.1ml/kg•h until 24h after PCI.

Primary outcomes

• the incidence of myocardial infarction type 4a (MI4a) [detect serum TnI level before and 3h、6h、12h、24h、48h after PCI]: serum troponin(TnI) values at 48h after PCI is an important indicator for diagnosis of acute myocardial injury myocardial damage when troponin I lever rise.

Secondary outcomes

• post-procedural cardiac function [once 3 months for 6 months after PCI]: Echocardiographic results can reflect cardiac function.Echocardiography index include left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV) and stroke volume (SV),doppler mitral flow E/A ratio(E/A).
• major adverse cardiac events(MACEs) [once 3 months for 12 months after PCI]: MACEs' incidence reflects the incidence of MI4a
• systemic inflammatory markers [before and 1 week after PCI]: systemic inflammatory markers can reflect the situation of cardiac injures,like tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),high-sensitivity C-reactive protein(hs-CRP).

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* the patients were coincided to CHD combined with depression and anxiety according to diagnostic standard of World Health Organization(WHO)who need receive selective PCI in the First Affiliated Hospital of Xi'an Jiaotong University;
* people aged over 18;
* patients who will undergo PCI with Hamilton Anxiety scale of 14 points or more.

Exclusion Criteria:

* severe comorbidity history;
* coronary stenosis less than 70%;
* severe cardiac dysfunction;
* central nervous system disease;
* troponin I levels have rised before entering the hospital;
* pregnant woman；
* history of mental disorders;
* alcoholic and long-term use of sedatives and opioids history;
* drug allergy history.

• Qiang Wang, PHD, Study chair, First Affiliated Hospital Xi'an Jiaotong University