Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST

NCT03044340 — Not applicable, Completed, 33 participants, Fondation Hôpital Saint-Joseph

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Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner

Registry	NCT03044340
Status	Completed
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, other
Enrollment	33 (Actual)
Sponsor	Fondation Hôpital Saint-Joseph (Other)
Conditions	Erythermalgia
Interventions	impedance measurement and pain evaluation (Other)
Dates	start 2017-01-12, primary completion 2018-01-18, completion 2019-04-17, first posted 2017-02-07, last updated 2019-04-25
Locations	1 site in France

-Summary

Erythromelalgy (EM) is a vascular syndrome very rare affecting the feet. This disease evolve by crisis when the feet extremities become red hot and painful. There are several types of EM but this study concern the adult primitive form. For a long time, the physiopathology was not described but now we know that there is a vascular form, with microcirculatory dysfunction and a neurologic form with small fibers neuropathy. The diagnostic of neurologic form is based on clinical evaluation (DN4 questionnaire, UENS scale...) and an electromyography. Thermotest, a medical device which measure the thermic sensitivity is used to quantify neuropathy. More recently Sudoscan, a device measuring cutaneous impedance to chloride ions detect small nervous fiber in diabetic patients with good correlation with Thermotest.

The purpose of this study is to analyze the vascular side and the neurologic side on patients consulting for Erythromelalgy.

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+Arms and interventions

Arm	Type	Interventions	Description
erythermalgia patient	Experimental	Other: impedance measurement and pain evaluation	patient will be measured chlorine ions impedance with the SUDOSCAN and evaluation on pain du to temperature with the THERMOTEST

impedance measurement and pain evaluation (Other): Measurement of chlorine ions impedance by SUDOSCAN and pain due to temperature evaluation with THERMOTEST

+Outcome measures

Primary outcomes

Assessment of Chlorine ion production change [Day1]: patient will be measured the impedance of chlorinates ions by Sudoscan
Assessment of Temperature changing sensitivity [Day1]: Patients will be measured their sensitivity to temperature changing using the Thermotest

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Pain with burn feeling at hands and feet extremities
* Crisis activated by the heat
* Age > 18 years old

Exclusion Criteria:

* Patients who had burn in extremities

+Locations (1)

Facility	City	Country	Status
Groupe Hospitalier Paris Saint Joseph	Paris, Île-de-France Region	France