Influence of Light on Sleep, Awakening, Electroencephalogram (EEG) and Cognitive Performances

• Application of white polychromatic light for 2h30 at different times of day (Other)

Primary outcomes

• Analysis of EEG activity [up to 56 hours]: sleep fragmentation
• Cognitive performances assessed using Psychomotor vigilance task (PVT) [up to 56 hours]: Psychomotor vigilance task (PVT)
• Cognitive performances assessed using Sustained Attention to Response Task (SART) [up to 56 hours]: Sustained Attention to Response Task (SART)
• Cognitive performances assessed using Digit Symbol Substitution Test (DSST) [up to 56 hours]: Digit Symbol Substitution Test (DSST)
• Cognitive performances assessed using N-back tasks [up to 56 hours]: N-back tasks
• Cognitive performances assessed using Paced Visual Serial Addition Task (PVSAT) [up to 56 hours]: Paced Visual Serial Addition Task (PVSAT)
• Cognitive performances assessed using Visual analogue scales (VAS) for motivation [up to 56 hours]: Visual analogue scales (VAS) for motivation
• Cognitive performances assessed using Positive and Negative Affect Scale (PANAS) [up to 56 hours]: Positive and Negative Affect Scale (PANAS)
• Cognitive performances assessed using Karolinska Sleepiness Scale (KSS) [up to 56 hours]: Karolinska Sleepiness Scale (KSS)
• Cognitive performances assessed using Visual Comfort Scale (VCS) [up to 56 hours]: Visual Comfort Scale (VCS)
• Cognitive performances assessed using Racing and Crowded Thoughts Questionnaire (RCTQ) [up to 56 hours]: Racing and Crowded Thoughts Questionnaire (RCTQ)
• Cognitive performances assessed using Mental Effort Rating Scale (RSME) [up to 56 hours]: Mental Effort Rating Scale (RSME)
• Cognitive performances assessed using Karolinska Drowsiness Test (KDT) [up to 56 hours]: Karolinska Drowsiness Test (KDT)

Sex: All, ages: 18 Years to 40 Years, accepts healthy volunteers

Inclusion Criteria:

* Male or female
* Aged 18 to 40 years
* With a hint of Bodymass index (BMI) between 17 and 30 kg.m - 2
* Healthy subject determined by a clinical examination, a psychological interview, a blood test, a urine analysis and an ophthalmologic examination
* Topic Subject with a score <6 questionnaire PSQI ("Sleep Questionnaire Pittsburgh")
* Subject agreeing to maintain a regular sleep/wake rhythm during the study
* Subject agreeing to refrain from caffeine, nicotine, alcohol, psychotropic drugs, cannabis or other drugs during the study
* Signed informed consent
* Subject affiliated to a social protection scheme

Exclusion Criteria:

* somatic diseases: cardiovascular, respiratory, gastrointestinal, hematopoietic, Visual
* immune system diseases
* kidneys and urinary tract diseases
* endocrine and metabolic diseases
* neurological diseases
* infectious diseases
* thrombocytopenia or other malfunction of blood platelets
* Subject with risk of thrombosis, including subject with a history of phlebitis, smoker under oral contraceptive...
* Subject with an addiction to caffeine, nicotine, alcohol, psychotropic drugs, cannabis, or any other drug
* Subject treatment contraindicated or inadvisable in combination with heparin
* Allergy to neoprene or lycra
* Dysfunction of the temporomandibular joint (TMJD)
* Blood donation in the previous 3 months before the inclusion
* Participation in other clinical trials in the previous 3 months before the inclusion
* Work by shifts in the year preceding the inclusion
* Trans-meridian travel (> 2 time zones) in the month previous the inclusion
* Contraindications to the use of the medical device
* Impossibility to give enlightened information (subject in an emergency situation, understanding difficulties,...)
* Subject under safeguard of justice
* Subject under tutorship or curatorship
* Pregnancy (women of childbearing age)
* Breastfeeding

• Results publication: Glacet R, Reynaud E, Robin-Choteau L, Reix N, Hugueny L, Ruppert E, Geoffroy PA, Kilic-Huck U, Comtet H, Bourgin P. A comparison of four methods to estimate dim light melatonin onset: a repeatability and agreement study. Chronobiol Int. 2023 Feb;40(2):123-131. doi: 10.1080/07420528.2022.2150554. Epub 2022 Dec 15. PMID 36519316
• Results publication: Walter A, Martz E, Weiner L, Comtet H, Glacet R, Kilic-Huck U, Bourgin P, Schroder CM, Weibel S. Sleep, rest-activity rhythm, cognitive and emotional symptoms in adult ADHD: unraveling the links with an actimetry-based approach. BMC Psychiatry. 2026 Mar 9;26(1):317. doi: 10.1186/s12888-026-07947-9. PMID 41803808