The Coexistence of Atherosclerotic Intracranial Arterial Stenosis With Intracranial Aneurysms

NCT02795078 — Unknown, 700 participants, liuxingju

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To Investigate the Coexistence of Atherosclerotic Intracranial Arterial Stenosis With Intracranial Aneurysms

RegistryNCT02795078, acronym CAIASA
StatusUnknown
Study typeObservational
Enrollment700 (Estimated)
Sponsorliuxingju (Other gov); collaborators: National Clinical Research Center for Neurological Diseases
ConditionsAtherosclerotic Intracranial Arterial Stenosis With Intracranial Aneurysms
Interventionsconservative treatment, Aneurysms clipping, Interventional embolization forAneurysms, stenting for stenosis (Drug, procedure)
Datesstart 2015-10-01, primary completion 2017-12-01 (estimated), completion 2018-03-01 (estimated), first posted 2016-06-09, last updated 2017-11-06
Locations1 site in China

Related Papers Related Patents Related Grants Related Experts
All trials for Atherosclerotic Intracranial Arterial Stenosis With Intracranial Aneurysms All trials of conservative treatment All trials of Aneurysms clipping

-Summary

Atherosclerotic intracranial arterial(ICA) stenosis and intracranial aneurysms are the common causes of ischemic stroke and hemorrhagic stroke, respectively. Investigators aimed to assess the prevalence of cerebral aneurysms in patients with atherosclerotic intracranial arterial stenosis.

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+Detailed description

Based on prospective data of patients with symptomatic or asymptomatic ICA stenosis admitted to Beijing Tiantan Hospital between Jan 2015 and July 2016, all patients underwent brain CTA / MRA/DSA. Investigators determined the number of the patients with intracranial aneurysms, calculated overall prevalence of the coexistence of atherosclerotic ICA stenosis with aneurysms and analyzed the clinical features.

+Arms and interventions

  • conservative treatment (Drug)
  • Aneurysms clipping (Procedure)
  • Interventional embolization forAneurysms (Procedure)
  • stenting for stenosis (Procedure)

+Outcome measures

Primary outcomes

  • new stroke events during perioperative period [perioperative period]

Secondary outcomes

  • stroke events during follow up [6 months after discharge]

+Eligibility

Sex: All, ages: 18 Years to 80 Years

Inclusion Criteria:

1. DSA identified the coexistence of intracranial Arterial Stenosis With Intracranial Aneurysms
2. Stenosis caused by atherosclerosis

Exclusion Criteria:

1. patients do not agree
2. Stenosis caused by no atherosclerosis disease

+Locations (1)

FacilityCityCountryStatus
Beijing Tiantan Hospital Capital Medical UniversityBeijing, Beijing MunicipalityChinaRecruiting

+Publications

  • Results publication: Yin Z, Zhang Q, Zhao Y, Lu J, Ge P, Xie H, Wu D, Yu S, Kang S, Zhang Q, Zhang Y, Zhang D, Zhao J, Liu X. Prevalence and Procedural Risk of Intracranial Atherosclerotic Stenosis Coexisting With Unruptured Intracranial Aneurysm. Stroke. 2023 Jun;54(6):1484-1493. doi: 10.1161/STROKEAHA.122.041553. Epub 2023 May 4. PMID 37139814