Rewarding Feedback in Motor Learning and Rehabilitation

NCT02189564 — Not applicable, Completed, 45 participants, Kai Lutz, PhD

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Die Auswirkung Von Dopaminergen Belohnungsreizen Auf Das Lernen Einer Motorischen Fertikgeit Bei Gesunden Probanden "Effects of Dopaminergic Reward on Motor Skill Learning in Healthy Subjects"

Registry	NCT02189564, acronym KFSP-REWARD
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: single, basic science
Enrollment	45 (Actual)
Sponsor	Kai Lutz, PhD (Industry); collaborators: University of Zurich
Conditions	Motor Performance, Motor Learning
Interventions	Feedback about good performance, Feedback about good performance + money, Feedback about average performance (Behavioral)
Dates	start 2014-01-01, primary completion 2014-07-01, completion 2016-04-01, first posted 2014-07-14, last updated 2016-05-02
Locations	1 site in Switzerland

-Summary

The effect of rewarding vs. non-rewarding feedback on acquisition of a motor skill is investigated in a single blinded parallel group design. Reward consists of performance dependent monetary reward, or of knowledge of performance in selected (above average) trials.

The investigators hypothesize improved motor skill learning and higher involvement of the dopaminsrgic system under rewarding vs. non-rewarding conditions.

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+Arms and interventions

Arm	Type	Interventions	Description
Intrinsic reward	Active comparator	Behavioral: Feedback about good performance	Feedback about good performance
Intrinsic and extrinsic reward	Experimental	Behavioral: Feedback about good performance + money	Feedback about good performance + money
Intrinsic reward (average performance)	Experimental	Behavioral: Feedback about average performance	Feedback about random selection of trials

Feedback about good performance (Behavioral)
Feedback about good performance + money (Behavioral)
Feedback about average performance (Behavioral)

+Outcome measures

Primary outcomes

Motor skill learning using an arc pointing task [about 10 minutes pre-training, about 10 min post training, about 24h post training]: temporal and spacial precision in an arc pointing task will be assessed using 5 different movement speeds during the above mentioned time periods before and after a specific motor learning programm. Learning will be assessed as change from pre-training to post training

+Eligibility

Sex: All, ages: 20 Years to 35 Years, accepts healthy volunteers

Inclusion Criteria:

* neurologically healthy
* right handed

Exclusion Criteria:

* Contraindications against magnetic resonance imaging
* pregnancy

+Locations (1)

Facility	City	Country	Status
Cereneo, Center For Rehabilitation and Neurology	Vitznau, Canton of Lucerne	Switzerland

+Publications

Results publication: Widmer M, Ziegler N, Held J, Luft A, Lutz K. Rewarding feedback promotes motor skill consolidation via striatal activity. Prog Brain Res. 2016;229:303-323. doi: 10.1016/bs.pbr.2016.05.006. Epub 2016 Jul 7. PMID 27926445

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