Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)

• 1 blood sample (Other)
• 2 to 3 blood samples (at inclusion, at 3 months and at 6 months in cases of relapse) (Other)

Primary outcomes

• Quantification of specific cytokines of the Th17 immune response (IL-17 A and IL-23) in the serum [Up to 6 months]
• Quantification of LTh17 by flow cytometry [Up to 6 months]
• Measurement of the activation level of genes specifically involved in Th17 response using RT-PCR on frozen mRNA [Up to 6 months]
• Measure the ability of Treg to proliferate and to synthesize IL-17 in response to different antigenic stimulations [Up to 6 months]

Sex: All, ages: 18 Years to 90 Years, accepts healthy volunteers

Inclusion Criteria:

Patients

* Patients who have provided written informed consent
* Patients with national health insurance cover
* Age: 50 to 90 years

Patients with Horton' s disease :

* at the diagnosis, before any treatment
* or in remission
* or in relapse

Patients with an infectious disease :

* Bacteriologically or radiologically confirmed
* Presenting an inflammatory syndrome defined by :
* CRP ≥ 10 mg / L
* and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1

Patients with neoplasia ( solid tumour or hemopathy ) :

* At the diagnosis, before treatment by chemotherapy
* Presenting an inflammatory syndrome defined by:
* CRP ≥ 10 mg / L
* and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1

Controls :

These are healthy volunteers recruited among blood donators at Dijon CHU, voluntary hospital personnel ( nurses, doctors and secretaries ), patients at the EPHAD ( Champmaillot centre for geriatric patients ) and patients without infectious, inflammatory, or auto-immune disease ( CRP < 5mg / L ) or cancer recruited from the investigating departments of Dijon CHU. They will be matched for age and sex.

* Age: 18 - 90 years
* Patients with national health insurance cover
* who have provided written informed consent
* Absence of an inflammatory syndrome ( CRP < 5 mg / L )

Exclusion Criteria :

* Any patient who does not meet the inclusion criteria