Mini-Mental State (MMS-LS) and Sign Language

NCT02005679 — Not applicable, Completed, 195 participants, Lille Catholic University
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Transposition of the Mini-Mental State in Sign Language

RegistryNCT02005679, acronym MMS-LS
StatusCompleted
PhaseNot applicable
Study typeInterventional; na, single group, masking: none, diagnostic
Enrollment195 (Actual)
SponsorLille Catholic University (Other)
ConditionsPrelingual Deafness, Retention Disorders, Cognitive
Interventionsapplication of the mini-mental state test (Behavioral)
Datesstart 2011-06-17, primary completion 2017-12-07, completion 2017-12-07, first posted 2013-12-09, last updated 2019-02-15
Locations4 sites in France

Related Papers Related Patents Related Grants Related Experts
All trials for Prelingual Deafness All trials for Retention Disorders, Cognitive All trials of application of the mini-mental state test

-Summary

In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants.

The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.

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+Detailed description

The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.

+Arms and interventions

ArmTypeInterventionsDescription
deaf persons with potential dementiaExperimentalBehavioral: application of the mini-mental state test
  • application of the mini-mental state test (Behavioral)

+Outcome measures

Primary outcomes

  • Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test [At baseline, 1 year and 2 years follow-up visits]

Secondary outcomes

  • Description of MMS-LS test results [Baseline]: Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members)
  • Diagnostic performance and predictive values of MMS-LS test for acquired dementia. [Baseline, 1 year and 2 years follow-up visits]: Sensitivity, specificity, positive and negative predictive values.
  • Correlation between MMS-LS score and CDR level [Baseline, 1 year and 2 years follow-up visits]: We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1.
  • Diagnostic performance and predictive values of MMS-LS test for suspected dementia. [Baseline, 1 year and 2 years follow-up visits]: Sensitivity, specificity, positive and negative predictive values

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Adults> 18 years
* Pre-lingual deafness
* Use of French sign language

Exclusion Criteria:

* Refusal to sign the consent
* Severe visual impairment with lower acuity (less than 0.5)
* Severe motor difficulties impeding the practice of sign language

+Locations (4)

FacilityCityCountryStatus
Hôpital de la Conception, Pôle psychiatrie CentreMarseille, Bouches-du-RhôneFrance
Groupement des Hôpitaux de l'Institut Catholique de LilleLille, Hauts-de-FranceFrance
CHU de Rennes, Hôpital de PontchaillouRennes, Ille-et-VilaineFrance
Unité Régionale d'Accueil et de Soins pour Sourds et malentendants - CHRU NancyNancy, Meurthe-et-MoselleFrance

+Publications

  • Results publication: Fleurion D, Vignal F, Drion B. Normative Data For Nonverbal Memory Tests In A Sample Of Deaf Adults that use French Sign Language. J Clin Exp Neuropsychol. 2025 Jul;47(5):495-507. doi: 10.1080/13803395.2025.2530564. Epub 2025 Jul 10. PMID 40640105

+Investigators

  • Benoît Drion, MD, Study director, Groupement des Hôpitaux de l'Institut Catholique de Lille, Unité d'Accueil et de Soins des Sourds en Langue des Signes et Réseau Sourds et Santé
  • Amélie Lansiaux, MD, Study chair, Groupement des Hôpitaux de l'Institut Catholique de Lille, Medical Research Department
  • Isabelle Ridoux, MD, Principal investigator, CHU de Rennes, Hôpital de Pontchaillou
  • Corine Gilda Scemama-Ammar, MD, Principal investigator, Hôpital de la Conception, Pôle psychiatrie, Marseille
  • Charlotte Crinquette, MD, Principal investigator, Groupement des Hôpitaux de l'Institut Catholique de Lille
  • Isabelle Bouillevaux, MD, Principal investigator, CHRU de Nancy, Unité Régionale d'Accueil et de Soins pour Sourds et malentendants