Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Daytime Slow Wave Sleep in Younger, Healthy Subjects
| Registry | NCT01840865 |
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| Status | Completed |
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| Phase | Not applicable |
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| Study type | Interventional; randomized, crossover, masking: triple, treatment |
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| Enrollment | 22 (Estimated) |
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| Sponsor | Charite University, Berlin, Germany (Other) |
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| Conditions | Healthy Subjects |
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| Interventions | brain stimulation, no stimulation (Device) |
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| Dates | start 2013-10-01, primary completion 2015-01-01, completion 2015-01-01, first posted 2013-04-26, last updated 2016-03-16 |
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| Locations | 1 site in Germany |
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Related Papers Related Patents Related Grants Related Experts
All trials for Healthy Subjects All trials of brain stimulation All trials of no stimulation
-Summary
The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.
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+Arms and interventions
| Arm | Type | Interventions | Description |
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| SHAM stimulation | Experimental | Device: no stimulation | SHAM stimulation during periods of Slow Wave Sleep |
| 0,75 Hz stimulation | Experimental | Device: brain stimulation | slow transcranial oscillating stimulation (\~0,75Hz) during periods of Slow Wave Sleep |
- brain stimulation (Device): oscillating direct current brain stimulation
- no stimulation (Device): sham Stimulation
+Outcome measures
Primary outcomes
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [4 weeks]: Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
Secondary outcomes
- Amount of Slow wave Sleep [4 weeks]: 1\. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- 2. sleep spindles [4 weeks]: 2\. Spindle activity during sleep indicated via several spindle parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- 3. EEG-correlates [4 weeks]: 3\. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- 4. further memory systems [4 weeks]: 4\. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
+Eligibility
Sex: All, ages: 18 Years to 35 Years, accepts healthy volunteers
Inclusion Criteria:
* healthy Subjects
* unobtrusive, neuropsychological screening
* age: 18-35 years
* right handed
Exclusion Criteria:
* untreated severe internal or psychiatric diseases
* epilepsy
* other severe neurological diseases eg., previous major stroke, brain tumour
* contraindications to MRI
+Locations (1)
| Facility | City | Country | Status |
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| Charite CCM Neurologie Berlin | Berlin, State of Berlin | Germany | |
+Publications
- Marshall L, Helgadottir H, Molle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. doi: 10.1038/nature05278. Epub 2006 Nov 5. PMID 17086200
- Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4. PMID 20046194
- Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi: 10.1016/j.bbr.2008.04.028. Epub 2008 May 8. PMID 18554731
- Mander BA, Santhanam S, Saletin JM, Walker MP. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 8;21(5):R183-4. doi: 10.1016/j.cub.2011.01.019. No abstract available. PMID 21377092
- Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci. 2003 Jul;6(7):697-8. doi: 10.1038/nn1078. PMID 12819785
- Results publication: Ladenbauer J, Ladenbauer J, Kulzow N, Floel A. Memory-relevant nap sleep physiology in healthy and pathological aging. Sleep. 2021 Jul 9;44(7):zsab002. doi: 10.1093/sleep/zsab002. PMID 33406266
+Investigators
- Agnes Flöel, Professor, Principal investigator, Charite Universitätsmedizin Berlin - Neurologie