Air Pollution, Inflammation and Acute Coronary Syndrome

NCT01799148 — Completed, 307 participants, Fundación Canaria Rafael Clavijo para la Investigación Biomédica

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Impact of AIR Pollution on Inflammation, Oxidative Stress and 1-year Prognosis in Patients Hospitalized for Acute COronary Syndrome

Registry	NCT01799148, acronym AIRACOS
Status	Completed
Study type	Observational
Enrollment	307 (Actual)
Sponsor	Fundación Canaria Rafael Clavijo para la Investigación Biomédica (Other)
Conditions	Patients With Acute Coronary Syndrome
Interventions	Particulate air pollutants (Other)
Dates	start 2011-11-01, primary completion 2014-07-01, completion 2014-11-01, first posted 2013-02-26, last updated 2015-01-21
Locations	1 site in Spain

-Summary

The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress. 2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.

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+Arms and interventions

Arm	Type	Interventions	Description
Particulate air pollutants		Other: Particulate air pollutants	Cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.

Particulate air pollutants (Other): We will determined the average concentrations of different sizes of particulate matter from 1 day or up to 7 days prior to admission in patients with acute coronary syndrome.

+Outcome measures

Primary outcomes

Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome. [7 days]: A single center, cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission. Also be determined inflammatory molecules and oxidative stress in admission.

Secondary outcomes

Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome. [1 year]: During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.

Other outcomes

Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome: [1 year]: During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.

+Eligibility

Sex: All, ages: 18 Years to 85 Years

Inclusion Criteria:

* Patients with acute coronary syndrome

Exclusion Criteria:

* Infectious process and / or local or systemic inflammation in the 15 days before admission.
* Thyrotoxicosis.
* Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.

+Locations (1)

Facility	City	Country	Status
Hospital Universitario de Canarias	San Cristóbal de La Laguna, Santa Cruz de Tenerife	Spain

+Publications

Results publication: Dominguez-Rodriguez A, Rodriguez S, Abreu-Gonzalez P, Avanzas P. [Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome: design of the AIRACOS study]. Med Clin (Barc). 2013 Dec 21;141(12):529-32. doi: 10.1016/j.medcli.2013.05.024. Epub 2013 Jul 25. No abstract available. Spanish. PMID 23891131