Polymorphids an mRNA Expression in Obese Genes

NCT01708083 — Completed, 50 participants, Karolinska Institutet

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Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue

Registry	NCT01708083
Status	Completed
Study type	Observational
Enrollment	50 (Actual)
Sponsor	Karolinska Institutet (Other)
Conditions	Polymorphism, mRNA Expression
Dates	start 2010-01-01, primary completion 2013-02-01, completion 2013-02-01, first posted 2012-10-16, last updated 2013-08-22
Locations	2 sites in Sweden

-Summary

Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).

Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .

Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue

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+Arms and interventions

Arm	Type	Interventions	Description
Type 2 Diabetes and BMI>35			Patients with type 2 diabetes and body mass index 35 or more.
BMI>35			Patients undergoing surgery, gastric bypass or cholecystectomy, without diabetes type 2 and body mass index 35 or more
BMI 18-27			Patients undergoing surgery, cholecystectomy or reflux, without type 2 diabetes and body mass index between 18-27

+Outcome measures

Primary outcomes

Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity [approximatly 30 minutes after start of operation]: fat biopsy taken from abdomen, omenta and thigh at surgery
Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2 [approximatly 30 minutes after start of operation]: fat biopsy; abdomen, omenta and thigh taken at surgery

+Eligibility

Sex: All, ages: 18 Years to 80 Years

Inclusion Criteria:

* age 18 years or older
* laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
* Normal weight without type 2 diabetes BMI 18-25
* Obese without type 2 diabetes BMI>35
* Obese with type 2 diabetes BMI>35

Exclusion Criteria:

* under 18 years
* open surgery
* pregnancy
* BMI >27-<35

+Locations (2)

Facility	City	Country	Status
Ersta hospital	Stockholm, Stockholm County Council	Sweden
Karolinska Institutet, CMM	Stockholm	Sweden

+Investigators

Anders Thorell, Ass. prof., Principal investigator, Karolinska Institutet