Glucose and Insulin Responses to Test Foods

• Reference Glucose (Other)
• Test Food 1 (Cereal) (Other)
• Test Food 2 (Biscuit) (Other)

Primary outcomes

• Postprandial Glucose Response [3 hours]

Secondary outcomes

• Postprandial Insulin Response [3 hours]

Sex: All, ages: 18 Years to 45 Years, accepts healthy volunteers

Inclusion Criteria:

* Participants will be non-smoking males or non-pregnant females aged 20-45y, with normal glycemia and in good health. A total of 12 participants will be included, where approximately half will be male \& half female, and half normal weight (BMI > 19.0 and < 25.0) and half overweight but not obese (BMI > 25.0 and < 30). Thus, no fewer than 5 male, 5 female, 5 normal weight and 5 overweight but not obese subjects will be included. Additional inclusion criteria will include:
* Absence of diabetes, impaired glucose tolerance and impaired fasting glucose, defined as having a fasting plasma glucose < 5.6 mmol/L (100 mg/dL) AND plasma glucose levels < 7.8 mmol/L (140 mg/dL) 2h after consumption of a 50 g glucose drink (OGTT will be administered during the screening visit)
* Systolic blood pressure 100-150 mmHg inclusive
* Diastolic blood pressure 60-90 mmHg inclusive
* Resting heart rate 50-90 beats/min inclusive after 3 minute rest
* Able to refrain from eating legumes and drinking alcohol the day before each test session
* Fasting triglycerides < 2.0 mmol/L (178 mg/dL)
* Fasting HDL cholesterol > 0.9 mmol/L (35 mg/dL) for males and > 1.1mmol/L (42 mg/dL) for females
* Fasting LDL cholesterol < 5.0 mmol/L (193 mg/dL)
* AST and ALT < 120% of upper limit of normal (ULN)
* hsCRP < 10 mg/L
* Urea and creatinine < 150% ULN

Exclusion Criteria:

* failure to meet any one of the inclusion criteria
* age less than 18 or over 45 years
* known history or AIDS, hepatitis, diabetes or a heart condition
* participants using medications or with any condition which might, in the opinion of Dr. Wolever, the president of GI Testing, either: 1) make participation dangerous to the subject or to others, or 2) affect the results
* participants who cannot or will not comply with the experimental procedures or do not follow GI Labs safety guidelines.
* Food allergies of any kind
* General anaesthesia in the month prior to inclusion.
* Smokers

• Thomas Wolever, MD, PhD, Principal investigator, Glycemic Index Laboratories, Inc