Intra Cranial EEG Activity During Dexmedetomidine Sedation

NCT01648959 — Terminated, 5 participants, University Health Network, Toronto

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Intra Cranial EEG Activity During Dexmedetomidine Sedation.Comparing the Effects of Dexmedetomidine on the Cortical and the Sub Cortical(Hippocampus) Structures.

Registry	NCT01648959
Status	Terminated - Lack of funding
Study type	Observational
Enrollment	5 (Actual)
Sponsor	University Health Network, Toronto (Other)
Conditions	Complex Partial Seizures
Interventions	EEG Recording (Other)
Dates	start 2012-07-01, primary completion 2014-03-01, completion 2014-03-01, first posted 2012-07-25, last updated 2022-12-22
Locations	1 site in Canada

-Summary

Various parts of the brain are sensitive to various anesthetics.We like to study the effect of dexmedetomidine on the different parts of the brain in patients who are coming for DBS electrode removal under sedation.

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+Detailed description

Cortical and sub cortical structures will have different sensitivities to various anesthetics.The objective of this study is to look at the changes in the intracranial electroencephalographic (EEG) characteristics during dexmedetomidine sedation and to determine the differences in the EEG characteristics between cortical and subcortical structures.

+Arms and interventions

EEG Recording (Other)

+Outcome measures

Primary outcomes

iEEG Recording [1 day]: iEEG data from each patient was analyzed using MATLAB (Natick, MA, USA). Data were presented as power spectral density, also referred to as the power spectrum or spectrum which quantifies the frequency distribution of energy or power within a signal. The spectrogram is a time-varying version of the spectrum. In these spectrograms, frequencies are arranged along the y-axis, and time along the x-axis, and power is indicated by color on a decibel (dB) scale. The power spectrum was computed for each channel using The Fast Fourier Transform (FFT). A window length of 20,000 data points was chosen in order to incorporate 4 cycles of a 1 Hz signal. The length of each window was therefore 4 seconds. A Hanning window was used to avoid edge effects of the windowing procedure. The length of the FFT was chosen to be 32768, which is the next power of 2 of the window length. The window overlap was set to zero.

+Eligibility

Sex: All, ages: 18 Years to 80 Years

Inclusion Criteria:

* Adults between 18 to 80 years of age, who are scheduled for elective removal of intracranial (surface and depth) electrodes under conscious sedation

Exclusion Criteria:

* Lack of informed consent
* Hypersensitivity to dexmedetomidine
* Language barrier
* Emergency surgery

+Posted results

Participant flow

Milestone	iEEG Activity
Started	5
Completed	5
Not completed	0

Outcome results

iEEG Recording (Primary), Mean, (Hz): iEEG Activity 8 (0 to 10)

Adverse events

Time frame: From the time of induction to the end of surgical procedure

Arm	Deaths	Serious adverse events	Other adverse events
iEEG Activity	0/5 (0.0%)	0/5 (0.0%)	0/5 (0.0%)

+Locations (1)

Facility	City	Country	Status
Toronto Western Hospital,UHN.	Toronto, Ontario	Canada

+Investigators

lashmikumar venkatraghavan, MD, Principal investigator, Assistant professor,Toronto western hospital,university health network (UHN)