Acceptability and Effectiveness of Household Water Treatment in Reducing Diarrhea Among Under Five Children

NCT01376440 — Phase 1, Completed, 845 participants, Haramaya Unversity

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Acceptability and Effectiveness of Household Water Chlorination in Reducing the Prevalence of Diarrhea Among Under Five Children in Eastern Ethiopia

RegistryNCT01376440
StatusCompleted
PhasePhase 1
Study typeInterventional; randomized, parallel, masking: none, prevention
Enrollment845 (Actual)
SponsorHaramaya Unversity (Other)
ConditionsAcute Diarrhoea
Interventionshousehold water treatment (Other)
Datesstart 2011-06-01, primary completion 2011-10-01, completion 2011-10-01, first posted 2011-06-20, last updated 2012-01-24
Locations1 site in Ethiopia

Related Papers Related Patents Related Grants Related Experts
All trials for Acute Diarrhoea All trials of household water treatment

-Summary

The Millenium development goals (MDGs) call for reducing by half the proportion of people without sustainable access to safe drinking water. This goal was adopted in large part because safe drinking water has been seen as critical to fighting diarrheal disease. Source protection is considered the main intervention area to achieve this goal. However, research worldwide that has shown that even drinking water which is safe at the source is subject to frequent and extensive fecal contamination during collection, storage and use in the home. This contamination is through the introduction of cups, dippers or hands, contamination by flies, cockroaches, and rats. Even piped water supplies of adequate microbial quality can pose infectious disease risks if they become contaminated due to unsanitary collection, storage conditions and practices within households.

To reduce this problem, point-of-use water treatment has been advocated as a means to substantially decrease the global burden of diarrhea and to contribute to the MDGs. However, research indicates that there are many unanswered questions around Household water treatment (HWT) that require small or medium scale epidemiological studies and randomized controlled trials, especially with regard to effectiveness, acceptability and identifying suitable target populations. Some of the most urgent questions to be resolved are:(1) How much of the currently cited disease reduction of HWT is due to bias? (2) What is the effect of HWT on nutritional status (weight gain and growth)?(3) At which populations should HWT be targeted? (4) Is it acceptable and sustainable in poor communities where the risk of diarrheal disease is high.

hypothesis: Do household water treatment with chlorine reduce diarrhea among underfive children? hypothesis: Do household water treatment with chlorine acceptable in the community?

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+Arms and interventions

ArmTypeInterventionsDescription
Household water treatmentExperimentalOther: household water treatmenthousehold water treatment with 1.25% sodium hypochlorite
controlNo interventionUsual practice (the use of "Jerrican" for water storage, which is considered as safe storage)
  • household water treatment (Other), also known as 1.25% sodium hypochlorite: household water treatment with 1.25% sodium hypochlorite

+Outcome measures

Primary outcomes

  • To assess the prevalence of diarrhea among under five children [four months]: weekly visit of the household for the presence of diarrhoea among underfive for four months in both the intervention and control groups

Secondary outcomes

  • To assess the weight gain among the intervention and control groups of under five children [At the beginning and end of the study ( 4 months interval)]: This is designed to assess whether there is weight gain (objective outcome) in children assigned to the intervention group compared to the control group. It is supplement to the prevalence of diarrhea which is subjective outcome for this study
  • Residual chlorine test [four months]: The use of the intervention (1.25% hypochlorite) is confirmed by the testing the residual chlorine weekly for for months from each household assigned in the intrevention group

+Eligibility

Sex: All, ages: 1 Month to 59 Months

Inclusion Criteria:

* All children under five years of age in the randomly selected clusters of Kersa district

Exclusion Criteria:

* seriously sick children in the randomly selected clusters of Kersa district

+Locations (1)

FacilityCityCountryStatus
Kersa districtKersa, Eastern HararageEthiopia

+Publications

  • Results publication: Mengistie B, Berhane Y, Worku A. Household water chlorination reduces incidence of diarrhea among under-five children in rural Ethiopia: a cluster randomized controlled trial. PLoS One. 2013 Oct 23;8(10):e77887. doi: 10.1371/journal.pone.0077887. eCollection 2013. PMID 24194899

+Investigators