The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics

NCT01246830 — Completed, 32 participants, Universitaire Ziekenhuizen KU Leuven

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Registry	NCT01246830
Status	Completed
Study type	Observational
Enrollment	32 (Actual)
Sponsor	Universitaire Ziekenhuizen KU Leuven (Other); collaborators: KU Leuven
Conditions	Orthodontics, Malocclusion, Impacted Tooth, Cephalometry, Cone-Beam Computed Tomography, Panoramic Radiography
Interventions	Panoramic radiograph, Cephalometric radiograph, Cone-beam computed tomography (CBCT) (Radiation)
Dates	start 2012-01-01, primary completion 2013-12-01, completion 2014-09-01, first posted 2010-11-23, last updated 2014-12-03
Locations	2 sites in Belgium

-Summary

Research questions:

1. Will the panoramic images derived from cone beam CT data give better diagnostic ability than conventional panoramic radiographs?
2. Will 3D cephalometric analysis offer the orthodontists and surgeons better information for treatment planning?
3. Will the 3D cephalometric analysis give more accurate treatment plan and better treatment outcome?

General hypothesis and special aims

Overall aims:

* To compare 2D versus 3D cephalometric analysis: treatment planning and therapeutic outcome.
* To determine the accuracy and diagnostic ability and usability of the 3D cephalometric analysis.
* To evaluate the diagnostic ability and usability of the panoramic image derived from cone beam CT data as compared to 2D panoramic images.
* To evaluate the value of the cone beam CT data in cephalometric analysing process for orthodontic and maxillofacial surgery treatment.

Hypotheses:

1. The availability of the 3D cephalometric analysis influences the orthodontic and maxillofacial treatment plan and decision, and might change the treatment outcome.
2. Panoramic images derived from cone beam CT data may provide equal information for diagnosis as conventional panoramic images.
3. Cone beam CT will be able to replace "classic orthodontic imaging" being more time and dose efficient and having a beneficial effect on treatment outcome.

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
3D cephalometric analysis		Radiation: Cone-beam computed tomography (CBCT)
2D cephalometric analysis		Radiation: Panoramic radiograph, Cephalometric radiograph

Panoramic radiograph, Cephalometric radiograph (Radiation): 2D images that are used for orthodontic treatment planning
Cone-beam computed tomography (CBCT) (Radiation): CBCT data will be used in 3D cephalometric analysis softwares

+Outcome measures

Primary outcomes

Cephalometric analysis [at treatment planning step and after 2 years of treatment]: linear and angular cephalometric measurement

Secondary outcomes

outcome of orthodontic treatment [after 2 years of treatment]

+Eligibility

Sex: All, ages: 12 Years to 25 Years

Inclusion Criteria:

* age 12-25 years old
* Patients with malocclusions
* Patients with jaw relation defect both with or without the need of orthognathic surgery
* Patients with maxillofacial defects: tumors and trauma
* Patients with eruption problems: embedded or impacted teeth which have to be removed

Exclusion Criteria:

* Patients with congenital deformities
* Patients with systemic diseases that may effect the growth formation: growth factor defect and thyroid hormone defect.

+Locations (2)

Facility	City	Country	Status
Katholieke Universiteit Leuven	Leuven	Belgium
University Hospital Leuven	Leuven	Belgium

+Publications

Broadbent BH. A new x-ray technique and its application to orthodontia. Angle Orthodontist 1931;51: 115-150
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Swennen GR, Schutyser F. Three-dimensional cephalometry: spiral multi-slice vs cone-beam computed tomography. Am J Orthod Dentofacial Orthop. 2006 Sep;130(3):410-6. doi: 10.1016/j.ajodo.2005.11.035. PMID 16979502
Olszewski R, Cosnard G, Macq B, Mahy P, Reychler H. 3D CT-based cephalometric analysis: 3D cephalometric theoretical concept and software. Neuroradiology. 2006 Nov;48(11):853-62. doi: 10.1007/s00234-006-0140-x. Epub 2006 Sep 29. PMID 17009024
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Hassan B, van der Stelt P, Sanderink G. Accuracy of three-dimensional measurements obtained from cone beam computed tomography surface-rendered images for cephalometric analysis: influence of patient scanning position. Eur J Orthod. 2009 Apr;31(2):129-34. doi: 10.1093/ejo/cjn088. Epub 2008 Dec 23. PMID 19106265
Lou L, Lagravere MO, Compton S, Major PW, Flores-Mir C. Accuracy of measurements and reliability of landmark identification with computed tomography (CT) techniques in the maxillofacial area: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Sep;104(3):402-11. doi: 10.1016/j.tripleo.2006.07.015. Epub 2006 Oct 27. PMID 17709072
de Oliveira AE, Cevidanes LH, Phillips C, Motta A, Burke B, Tyndall D. Observer reliability of three-dimensional cephalometric landmark identification on cone-beam computerized tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Feb;107(2):256-65. doi: 10.1016/j.tripleo.2008.05.039. Epub 2008 Aug 20. PMID 18718796
Periago DR, Scarfe WC, Moshiri M, Scheetz JP, Silveira AM, Farman AG. Linear accuracy and reliability of cone beam CT derived 3-dimensional images constructed using an orthodontic volumetric rendering program. Angle Orthod. 2008 May;78(3):387-95. doi: 10.2319/122106-52.1. PMID 18416632
Brown AA, Scarfe WC, Scheetz JP, Silveira AM, Farman AG. Linear accuracy of cone beam CT derived 3D images. Angle Orthod. 2009 Jan;79(1):150-7. doi: 10.2319/122407-599.1. PMID 19123719
Olszewski R, Tanesy O, Cosnard G, Zech F, Reychler H. Reproducibility of osseous landmarks used for computed tomography based three-dimensional cephalometric analyses. J Craniomaxillofac Surg. 2010 Apr;38(3):214-21. doi: 10.1016/j.jcms.2009.05.005. Epub 2009 Jul 1. PMID 19574058
Proffit WR, Fields HW Jr., Sarver DM. Contemporary Orthodontics. 4th ed, Mosby Inc., Elsevier Science, Philadelphia, 2006.
White SC, Pharoah MJ. The evolution and application of dental maxillofacial imaging modalities. Dent Clin North Am. 2008 Oct;52(4):689-705, v. doi: 10.1016/j.cden.2008.05.006. PMID 18805224