The Effect of Local Injectet GH on the Collagen Synthesis in the Ligamentum Patella

NCT01158612 — Not applicable, Completed, 12 participants, University of Aarhus

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Registry	NCT01158612
Status	Completed
Phase	Not applicable
Study type	Interventional; non randomized, parallel, masking: double, treatment
Enrollment	12 (Actual)
Sponsor	University of Aarhus (Other); collaborators: Bispebjerg Hospital
Conditions	Growth Hormone, Elderly
Interventions	Growth Hormone (Drug)
Dates	start 2010-08-01, primary completion 2011-07-01, completion 2011-08-01, first posted 2010-07-08, last updated 2011-11-07
Locations	1 site in Denmark

-Summary

Tendon and ligament injuries are a frequent problem among athletes but also in the general population. The healing process is a prolonged process, and complete recovery of tissue strength is nearly never reached. The purpose of this study is to examine the effect of local injection of human Growth Hormone on tendon collagen synthesis.

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+Detailed description

in order to investigate the collagen synthesis potential and the influence of growth hormone, 12 elderly males age > 50 year, is enrolled in this study.

+Arms and interventions

Arm	Type	Interventions	Description
Growth hormone	Experimental	Drug: Growth Hormone	The effect of Growth hormone on the collagen synthesis rate
Saline	Placebo comparator	Drug: Growth Hormone

Growth Hormone (Drug), also known as infusion of Saline in the patella tendon.: infusion of Growth hormone in the patella tendon.

+Outcome measures

Primary outcomes

• Fraktionele collagen protein synthesis in human patella tendon [01122010]

+Eligibility

Sex: Male, ages: 55 Years to 70 Years, accepts healthy volunteers

Inclusion Criteria:

* BMI 18.5 - 25.0

Exclusion Criteria:

* earlier knee injury

+Locations (1)

Facility	City	Country	Status
Århus universitetshospital nørrebrogade 44	Århus C	Denmark

+Investigators

Mette Hansen, PH.D., Principal investigator